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Stimuli-responsive nano-assemblies for remotely controlled drug delivery.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.jconrel.2020.03.051 Fangyuan Li 1 , Yu Qin 2 , Jiyoung Lee 3 , Hongwei Liao 3 , Nan Wang 3 , Thomas P Davis 4 , Ruirui Qiao 4 , Daishun Ling 5
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.jconrel.2020.03.051 Fangyuan Li 1 , Yu Qin 2 , Jiyoung Lee 3 , Hongwei Liao 3 , Nan Wang 3 , Thomas P Davis 4 , Ruirui Qiao 4 , Daishun Ling 5
Affiliation
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Stimuli-responsive nano-assemblies are emerging as promising drug delivery systems (DDSs) with spatial and temporal tenability, which can undergo structural transition for controlled drug release upon excitation by either exogenous or endogenous stimuli. Particularly, exogenous stimuli-responsive nano-assemblies based remotely controlled DDSs, have received much attention due to their accuracy and reliability realized by tunable exogenous triggers such as light, magnetic field, or temperature. In this review, we will briefly introduce the current state-of-the-art technologies of nano-assembly synthesis and summarize the recent advances in remotely controlled nano-assembly-based DDSs activated by different exogenous stimuli or endogenous/exogenous dual-stimuli. Furthermore, the pioneering progress in bio-cleanable stimuli-responsive nano-assemblies that holds great relevance to clinical translation will be described. Finally, we will conclude with our perspectives on current issues and future development of this field. The objective of this review is to outline current advances of nano-assemblies as remotely controlled DDSs, in hopes of accelerating the future development of intelligent nanomedicines.
中文翻译：
刺激响应的纳米组件，用于远程控制药物输送。
刺激响应的纳米组件正在发展成为具有时空稳定性的有前途的药物传递系统（DDSs），在受到外源或内源性刺激激发后，可以经历结构转变以控制药物的释放。特别地，基于外源刺激响应纳米组件的远程控制DDS，由于其通过可调外源触发器（例如光，磁场或温度）实现的准确性和可靠性而受到广泛关注。在这篇综述中，我们将简要介绍纳米组装合成的最新技术，并总结由不同的外源刺激或内源/外源双重刺激激活的基于远程纳米组装的DDS的最新进展。此外，将描述与临床翻译密切相关的可生物清洁的刺激响应性纳米组件的开创性进展。最后，我们将以对当前问题和该领域未来发展的观点作为结束。这篇综述的目的是概述作为远程控制DDS的纳米组件的最新进展，以期加速智能纳米药物的未来发展。
更新日期：2020-04-08
中文翻译：
刺激响应的纳米组件，用于远程控制药物输送。
刺激响应的纳米组件正在发展成为具有时空稳定性的有前途的药物传递系统（DDSs），在受到外源或内源性刺激激发后，可以经历结构转变以控制药物的释放。特别地，基于外源刺激响应纳米组件的远程控制DDS，由于其通过可调外源触发器（例如光，磁场或温度）实现的准确性和可靠性而受到广泛关注。在这篇综述中，我们将简要介绍纳米组装合成的最新技术，并总结由不同的外源刺激或内源/外源双重刺激激活的基于远程纳米组装的DDS的最新进展。此外，将描述与临床翻译密切相关的可生物清洁的刺激响应性纳米组件的开创性进展。最后，我们将以对当前问题和该领域未来发展的观点作为结束。这篇综述的目的是概述作为远程控制DDS的纳米组件的最新进展，以期加速智能纳米药物的未来发展。
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