Rubusoside alleviates the ovalbumin-induced mice allergic asthma by modulating the NF-κB activation.,Journal of Food Biochemistry

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Rubusoside alleviates the ovalbumin-induced mice allergic asthma by modulating the NF-κB activation.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-17 , DOI: 10.1111/jfbc.13187
Chengqiang Wang ₁ , Jia Tang ₂ , Bo Qian ₁ , Zhen Zeng ₁ , Yang Gao ₃ , Jia-Le Song _{1,

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Affiliation

The anti‐inflammatory and anti‐asthmatic effects of rubusoside (Rbs) were investigated in the ovalbumin (OVA)‐induced asthmatic mice, followed by effective attenuation of Rbs treatment on the airway hyperresponsiveness and reduction of inflammatory cells inside the bronchoalveolar lavage fluid (BALF). The mitigation of inflammatory infiltration as a result of Rbs treatment was histologically observed in these mice lungs. Rbs contributed to the decrease of inflammatory cytokines (TNF‐α, IL‐13, IL‐6, IL‐5, and IL‐4) inside the BALF of mice with asthma. A decline of OVA‐dependent IgE and IgG1 inside the serum was also noticed in these mice. Rbs was proved to enhance the mRNA level of Foxp3 inside the mice lung affected with asthma while decrease that of IL‐17A, IL‐23, and RORγt. NF‐κB pathway activation elicited by OVA was suppressed by Rbs inside the pulmonary tissues. Rbs played significantly in the reduction of airway inflammation induced by OVA which with modulating NF‐κB pathway activation.

中文翻译：

红景天苷通过调节NF-κB活化减轻卵白蛋白诱发的小鼠过敏性哮喘。

在卵白蛋白（OVA）诱发的哮喘小鼠中研究了红景天苷（Rbs）的抗炎和抗哮喘作用，然后有效减弱Rbs对气道高反应性的治疗作用并减少支气管肺泡灌洗液（BALF）中的炎症细胞）。在这些小鼠的肺中，从组织学上观察到了Rbs治疗导致的炎症浸润的减轻。Rb有助于减少哮喘小鼠BALF中的炎症细胞因子（TNF-α，IL-13，IL-6，IL-5和IL-4）。在这些小鼠中还发现血清中OVA依赖的IgE和IgG1下降。事实证明，Rbs可以增强哮喘小鼠肺内Foxp3的mRNA水平，同时降低IL-17A，IL-23和RORγt的水平。OVA引起的NF-κB途径激活被肺组织内部的Rb抑制。Rbs通过调节NF-κB途径的激活在OVA引起的气道炎症的减轻中起着重要作用。

更新日期：2020-03-17

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