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The synergistic effect of cell wall extracted from probiotic biomass containing Lactobacillus acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2 on the anticancer activity of cranberry juice-HPLC fractions.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-17 , DOI: 10.1111/jfbc.13195
Kerlynn Desrouillères 1 , Mathieu Millette 2 , Leila Bagheri 1 , Behnoush Maherani 1 , Majid Jamshidian 1 , Monique Lacroix 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-17 , DOI: 10.1111/jfbc.13195
Kerlynn Desrouillères 1 , Mathieu Millette 2 , Leila Bagheri 1 , Behnoush Maherani 1 , Majid Jamshidian 1 , Monique Lacroix 1
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Anticancer effects were evaluated on three HPLC fractions obtained from a concentrated cranberry juice and cell wall constituents extracted from a probiotic biomass containing Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2. The samples were tested at increasing concentrations for the antiproliferative assay using HT‐29 cells' line and for the quinone reductase (QR) assay using Hepa‐1c1c7 murine hepatoma cells. Fraction 1 (F1) which is highly concentrated with phenolic acids inhibited the growth of the HT‐29 cells' line with IC50 values of 14.80 µg Gallic acid equivalent (GAE)/ml. The fraction 3 (F3) which is highly concentrated in flavonols had potency as QR inducer. Furthermore, the results showed that all cranberry fractions combined with cell wall constituents extracted from the probiotic biomass were more effective in inhibiting the growth of HT‐29 as compared to the cranberry fractions tested alone, indicating a possible synergy effect between these bio‐functional compounds.
中文翻译：
从含有嗜酸乳杆菌CL1285，干酪乳杆菌LBC80R和鼠李糖乳杆菌CLR2的益生菌生物质中提取的细胞壁对蔓越莓汁HPLC组分的抗癌活性具有协同作用。
从浓缩的酸果蔓汁和从含有嗜酸乳杆菌CL1285，干酪乳杆菌LBC80R和鼠李糖乳杆菌CLR2的益生菌生物质中提取的细胞壁成分评估了三种HPLC组分的抗癌作用。使用HT-29细胞系对样品进行了浓度递增的抗增殖试验以及使用Hepa-1c1c7鼠肝细胞瘤细胞的醌还原酶（QR）试验。富含酚酸的组分1（F1）通过IC 50抑制了HT‐29细胞系的生长值14.80 µg没食子酸当量（GAE）/ ml。在黄酮醇中高度浓缩的级分3（F3）具有作为QR诱导剂的潜力。此外，结果表明，与单独测试的蔓越莓级分相比，所有从益生菌生物质中提取的蔓越莓级分和细胞壁成分均能更有效地抑制HT-29的生长，表明这些生物功能化合物之间可能存在协同作用。
更新日期：2020-03-17
中文翻译：
从含有嗜酸乳杆菌CL1285，干酪乳杆菌LBC80R和鼠李糖乳杆菌CLR2的益生菌生物质中提取的细胞壁对蔓越莓汁HPLC组分的抗癌活性具有协同作用。
从浓缩的酸果蔓汁和从含有嗜酸乳杆菌CL1285，干酪乳杆菌LBC80R和鼠李糖乳杆菌CLR2的益生菌生物质中提取的细胞壁成分评估了三种HPLC组分的抗癌作用。使用HT-29细胞系对样品进行了浓度递增的抗增殖试验以及使用Hepa-1c1c7鼠肝细胞瘤细胞的醌还原酶（QR）试验。富含酚酸的组分1（F1）通过IC 50抑制了HT‐29细胞系的生长值14.80 µg没食子酸当量（GAE）/ ml。在黄酮醇中高度浓缩的级分3（F3）具有作为QR诱导剂的潜力。此外，结果表明，与单独测试的蔓越莓级分相比，所有从益生菌生物质中提取的蔓越莓级分和细胞壁成分均能更有效地抑制HT-29的生长，表明这些生物功能化合物之间可能存在协同作用。
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