One new bisabolane‐type sesquiterpenoid, together with four known bisabolane‐type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR‐ESI‐MS, and NMR) data analysis. The possible anti‐Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β‐hydroxybisabola‐2,10‐dien‐4‐one had the highest possible anti‐AD activity.

中文翻译：

---

姜黄根茎中红没药烷型倍半萜衍生物和酚类物质的分离、表征和可能的抗阿尔茨海默病活性

从姜黄的根茎中分离出一种新的红没药型倍半萜，连同四种已知的红没药型倍半萜衍生物和七种酚类物质。通过广泛的光谱（IR、HR-ESI-MS 和 NMR）数据分析阐明了它们的结构。还使用秀丽隐杆线虫 AD 病理模型评估了分离化合物可能的抗阿尔茨海默病 (AD) 活性，并且 1β-羟基红糖-2,10-dien-4-one 具有最高的抗 AD 活性。