Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.,Advanced Science

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Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.
Advanced Science ( IF 14.3 ) Pub Date : 2020-04-06 , DOI: 10.1002/advs.201903585
Weiwei Su ₁ , Han Wang _{2,

3} , Tao Wang ₁ , Xiao Li ₁ , Zhongmin Tang _{2,

3} , Shuai Zhao ₁ , Meng Zhang _{2,

3} , Danni Li ₁ , Xingwu Jiang ₄ , Teng Gong ₅ , Wei Yang _{3,

5} , Changjing Zuo ₁ , Yelin Wu ₄ , Wenbo Bu _{3,

5}

Affiliation

Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (125I) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125I-TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the O-H bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.

中文翻译：

俄歇电子在纳米催化剂上构建了用于催化体内放射治疗的活性位点。

多余的电子对于纳米催化剂表面活性位点的构建起着重要作用。然而，在体内向纳米催化剂提供多余的电子仍然是一个挑战，这限制了纳米催化剂在生物医学中的应用。在此，从放射性核素125（125I）发射的俄歇电子（AE）被原位用于构建纳米催化剂（TiO2）中的活性位点，并且该方法的应用进一步扩展到癌症催化内部放射治疗（CIRT）。获得的 125I-TiO2 纳米粒子首先通过 Ti4+ 与 AE 之间的反应构建表面 Ti3+ 活性位点。然后Ti3+拉伸并削弱所吸收的H2O的OH键，从而增强H2O分子的辐射分解并产生羟基自由基(·OH)。所有体外和体内结果均显示出良好的 CIRT 性能。这些发现将拓宽放射性核素的应用，并为纳米医学引入新的视角。

更新日期：2020-04-06

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