In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy.,Nature Communications

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In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy.
Nature Communications ( IF 14.7 ) Pub Date : 2020-04-07 , DOI: 10.1038/s41467-020-15427-1
Yannan Liu ₁ , Hao Wang ₂ , Shanlong Li ₁ , Chuanshuang Chen ₁ , Li Xu _{1,

3} , Ping Huang _{1,

3} , Feng Liu ₁ , Yue Su ₁ , Meiwei Qi ₁ , Chunyang Yu ₁ , Yongfeng Zhou ₁

Affiliation

Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π-π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.

中文翻译：

原位超分子聚合增强聚合物囊泡的自组装，用于高效光热疗法。

在光热疗法（PTT）中，非常需要水泡光热疗法剂（PTA），因为它们具有出色的光收集能力和多功能的中空隔室。然而，到目前为止，所报道的囊泡PTA通常是由脂质体等小分子自组装而成的，由于发色团在囊膜中的不规则堆积导致光热转化效率不令人满意，因此很少将聚合物囊泡用作PTA。在这里，我们报道了由超支化多卟啉形成的纳米级聚合物囊泡，具有良好的光热稳定性和极高的光热效率（44.1％），在体外和体内实验中，在影像引导的PTT肿瘤研究中显示出巨大的潜力。这些优异的性能归因于囊泡膜内卟啉单元的原位超分子聚合为由π-π堆积驱动的组织良好的一维单丝。我们相信，本文报道的超分子聚合增强的自组装过程将为具有新结构和功能的超分子材料的设计提供新的思路。

更新日期：2020-04-24

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