4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector.,Journal of Medicinal Chemistry

当前位置： X-MOL 学术 › J. Med. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector.
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-04-07 , DOI: 10.1021/acs.jmedchem.9b02115
Wenxian Zhou ₁ , Zhiguang Qiao _{2,

3} , Ehsan Nazarzadeh Zare ₄ , Jinfeng Huang ₁ , Xuanqi Zheng ₁ , Xiaolei Sun ₅ , Minmin Shao ₆ , Hui Wang ₁ , Xiaoyan Wang ₇ , Dong Chen ₁ , Jing Zheng ₈ , Shan Fang ₉ , Yan Michael Li ₁₀ , Xiaolei Zhang ₁ , Lei Yang ₁ , Pooyan Makvandi _{11,

12,

13} , Aimin Wu ₁

Affiliation

Department of Orthopaedics, Bioprinting Research Group, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Medical 3D Printing Center, Shanghai Jiaotong University, Shanghai 200011, China.
Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
School of Chemistry, Damghan University, Damghan 36716-41167, Iran.
Department of Orthopaedics, Tianjin Hospital, Tianjin 300210, China.
Department of ENT and Neck Surgery, Wenzhou Center Hospital, Dingli Hospital of Wenzhou Medical University, Wenzhou Institute of Medical Sciences, Wenzhou 325000, China.
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China.
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200050, China.
Department of Neurosurgery and Oncology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, New York 14642, United States.
Institute for Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Naples 80125, Italy.
Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 61537-53843, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.

Most of the biomedical materials printed using 3D bioprinting are static and are unable to alter/transform with dynamic changes in the internal environment of the body. The emergence of four-dimensional (4D) printing addresses this problem. By preprogramming dynamic polymer materials and their nanocomposites, 4D printing is able to produce the desired shapes or transform functions under specific conditions or stimuli to better adapt to the surrounding environment. In this review, the current and potential applications of 4D-printed materials are introduced in different aspects of the biomedical field, e.g., tissue engineering, drug delivery, and sensors. In addition, the existing limitations and possible solutions are discussed. Finally, the current limitations of 4D-printed materials along with their future perspective are presented to provide a basis for future research.

中文翻译：

生物医学应用中的4D打印动态材料：化学，挑战及其在临床领域中的未来前景。

使用3D生物打印技术打印的大多数生物医学材料都是静态的，无法随着人体内部环境的动态变化而改变/变换。二维（4D）打印的出现解决了这个问题。通过对动态聚合物材料及其纳米复合材料进行预编程，4D打印能够在特定条件或刺激下产生所需的形状或转换功能，以更好地适应周围环境。在这篇综述中，在生物医学领域的不同方面介绍了4D打印材料的当前和潜在应用，例如组织工程，药物输送和传感器。此外，还讨论了现有限制和可能的解决方案。最后，

更新日期：2020-04-07

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南