β-Cyclodextrin-Self-Assembled Nanochannel Membrane for the Separation of Chiral Drugs,ACS Applied Nano Materials

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β-Cyclodextrin-Self-Assembled Nanochannel Membrane for the Separation of Chiral Drugs
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-04-07 , DOI: 10.1021/acsanm.0c00481
Siyun Zhang ₁ , Xue Chen ₁ , Lingda Sun ₁ , Haibing Li ₁

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The fabrication of a membrane with the capability of chiral selective transport is a big challenge in the membrane separation of chiral drugs. To solve the problem of chiral selectivity in membrane separation, drug/metabolite transport (DMT) in the cell membrane inspires a bionic strategy based on the nanochannel membrane. Herein, the DMT-inspired nanochannel membrane is fabricated by the self-assembly of cyclodextrin (CD) in nanochannels and used for the chiral transport and separation of model chiral drugs such as naproxen (NAP). As a result, the β-CD-self-assembled nanochannel membrane shows chiral transport of (S)-naproxen (S-NAP) and achieves the chiral separation of racemic drugs. Moreover, a mechanism of chiral separation is proposed that the chiral selective interaction increases the surface charge density, causing chiral enrichment and transport. Given these promising results, the study of the β-CD-self-assembled nanochannel membrane suggests a bionic strategy for the separation of chiral drugs.

中文翻译：

β-环糊精自组装纳米通道膜用于手性药物的分离

具有手性选择性转运能力的膜的制备是手性药物膜分离中的一大挑战。为了解决膜分离中的手性选择性问题，细胞膜中的药物/代谢物运输（DMT）激发了基于纳米通道膜的仿生策略。本文中，DMT启发的纳米通道膜是通过在纳米通道中自组装环糊精（CD）制成的，用于手性转运和分离手性药物如萘普生（NAP）等模型。结果，β-CD-自组装的纳米通道膜表现出（S萘普生（S-NAP）并实现外消旋药物的手性分离。此外，提出了一种手性分离的机理，即手性选择性相互作用增加了表面电荷密度，引起手性富集和转运。鉴于这些令人鼓舞的结果，对β-CD-自组装纳米通道膜的研究提出了一种手性药物分离的仿生策略。

更新日期：2020-04-07

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