Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity,Allergy

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Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity
Allergy ( IF 12.6 ) Pub Date : 2020-05-27 , DOI: 10.1111/all.14298
Adriana Ariza ₁ , Rubén Fernández-Santamaría ₁ , Xiaoli Meng ₂ , María Salas _{1,

3} , Monday O Ogese ₂ , Arun Tailor ₂ , Gádor Bogas _{1,

3} , María José Torres _{1,

3,

4,

5} , Dean J Naisbitt ₂

Affiliation

Betalactam (BL) antibiotics are the most common cause of drug hypersensitivity. Amoxicillin (AX), which is often prescribed alongside clavulanic acid (Clav), is the most common elicitor. The aim of this study was to determine whether AX and Clav‐responsive T‐cells are detectable in patients with immediate hypersensitivity to AX‐Clav, to assess whether these T‐cells display the same specificity as that detected in skin and provocation testing, and to explore T‐cell activation pathways.

中文翻译：

来自药物速发型过敏症患者的阿莫西林和克拉维酸特异性 T 细胞克隆的表征

倍内酰胺 (BL) 抗生素是药物过敏的最常见原因。阿莫西林 (AX) 通常与克拉维酸 (Clav) 一起使用，是最常见的引发剂。本研究的目的是确定对 AX-Clav 立即过敏的患者是否可以检测到 AX 和 Clav 反应性 T 细胞，评估这些 T 细胞是否表现出与皮肤和激发试验中检测到的相同的特异性，以及探索T细胞激活途径。

更新日期：2020-05-27

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