<br>蛋壳膜粉通过调节肠道微生物群和加速高脂肪饮食喂养小鼠的脂质代谢来降低血浆甘油三酯和肝脏总胆固醇。,Food Science & Nutrition

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蛋壳膜粉通过调节肠道微生物群和加速高脂肪饮食喂养小鼠的脂质代谢来降低血浆甘油三酯和肝脏总胆固醇。
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-04-05 , DOI: 10.1002/fsn3.1545
Nurul Shazini Ramli _{1,

2} , Huijuan Jia ₁ , Ayumu Sekine ₁ , Weida Lyu ₁ , Kyohei Furukawa ₁ , Kenji Saito ₁ , Yukio Hasebe ₃ , Hisanori Kato ₁

Affiliation

肥胖是一种与肠道菌群相关的全球主要生活方式障碍。之前的报告已经证明了蛋壳膜 (ESM) 的健康益处，特别是在肠道微生物群组成方面。在这里，我们研究了 ESM 是否可以改善高脂饮食喂养小鼠的脂质代谢并改变肠道微生物群。总共 20 只 6 周龄的 C57BL/6J 小鼠接受对照饮食 (CON)、高脂饮食 (HFD) 或高脂饮食 + 8% ESM 粉末 (HESM) 20 周。 HFD 喂养的小鼠补充 ESM 降低了血浆甘油三酯 (TG) 和肝脏总胆固醇 (TC)，并上调了脂质代谢基因肉毒碱棕榈酰转移酶 1A 和细胞因子信号传导抑制因子 2 的表达。微生物群分析显示抗肥胖细菌的相对丰度增加、罗伊氏乳杆菌（在第 4、12 和 16 周时），并在第 12 和 20 周时减少了与炎症相关的氢营养布劳氏菌 (Blautia Hydronotropicica) 、粪罗斯伯里氏菌 (Roseburia faecis ) 和愈伤瘤胃球菌 (Ruminococcus callidus)的丰度。补充 ESM 的小鼠盲肠异丁酸增加，与B. Hydronotropicica和Parabacteroides goldsteinii丰度呈负相关。结果表明，HFD 喂养的小鼠补充 ESM 可能通过改变脂质代谢基因表达和肠道微生物群组成来降低血浆 TG 和肝脏 TC，这表明 ESM 可能对肥胖管理有效。

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Eggshell membrane powder lowers plasma triglyceride and liver total cholesterol by modulating gut microbiota and accelerating lipid metabolism in high-fat diet-fed mice.

Obesity is a major global lifestyle disorder associated with gut microbiota. The health benefits of eggshell membrane (ESM) have been shown in previous reports, particularly as regards gut microbiota composition. Here, we investigated whether ESM improves lipid metabolism and alters gut microbiota in high‐fat diet‐fed mice. A total of 20 C57BL/6J mice aged 6 weeks were given either a control diet (CON), high‐fat diet (HFD), or high‐fat diet + 8% ESM powder (HESM) for 20 weeks. ESM supplementation in HFD‐fed mice reduced plasma triglycerides (TG) and liver total cholesterol (TC) and upregulated the expression of lipid metabolism genes carnitine palmitoyltransferase 1A and suppressor of cytokine signaling 2. Microbiota analysis showed increased relative abundance of the anti‐obesity bacterium, Lactobacillus reuteri, at 4, 12, and 16 weeks and reduced the abundance of inflammation‐related Blautia hydrogenotrophica, Roseburia faecis, and Ruminococcus callidus at 12 and 20 weeks. ESM‐supplemented mice had increased cecal isobutyrate, negatively correlated with B. hydrogenotrophica and Parabacteroides goldsteinii abundance. The results indicate that ESM supplementation in HFD‐fed mice reduced plasma TG and liver TC, possibly through alteration of lipid metabolism gene expression and gut microbiota composition, suggesting that ESM may be effective in obesity management.

更新日期：2020-04-05

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