Immunotoxicities of microplastics and sertraline, alone and in combination, to a bivalve species: size-dependent interaction and potential toxication mechanism.,Journal of Hazardous Materials

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Immunotoxicities of microplastics and sertraline, alone and in combination, to a bivalve species: size-dependent interaction and potential toxication mechanism.
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2020-04-03 , DOI: 10.1016/j.jhazmat.2020.122603
Wei Shi ₁ , Yu Han ₁ , Shuge Sun ₁ , Yu Tang ₁ , Weishang Zhou ₁ , Xueying Du ₁ , Guangxu Liu ₁

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Although coexposure to pharmaceuticals and microplastics (MPs) may frequently occur, the synergistic impact of MPs and antidepressants on marine species still remains poorly understood. In this study, the immunotoxicities of polystyrene MPs (diameters 500 nm and 30 μm) and sertraline (Ser), alone and in combination, were investigated in a bivalve mollusk Tegillarca granosa. Results showed that both MPs and Ser significantly suppressed the immune responses of T. granosa. In addition, though the toxic effect of Ser was not affected by microscale MPs, an evident synergistic immuno-toxic effect was observed between Ser and nanoscale MPs, which indicates a size-dependent interaction between the two. To further ascertain the underlying toxication mechanisms, the intracellular content of reactive oxygen species, apoptosis status, ATP content, pyruvate kinase activity, plasma cortisol level, and in vivo concentrations of neurotransmitters and cytochrome P450 1A1 were analysed. A transcriptomic analysis was also performed to reveal global molecular alterations following Ser and/or MPs exposure. The obtained results indicated that the presence of nanoscale MPs may enhance the immunotoxicity of Ser by (i) inducing apoptosis of haemocytes and, hence, reducing the THC; (ii) constraining the energy availability for phagocytosis; and (iii) hampering the detoxification of Ser.

中文翻译：

微塑料和舍曲林对双壳类动物的免疫毒性：大小相关的相互作用和潜在的毒性机制。

尽管经常接触药物和微塑料（MP），但MP和抗抑郁药对海洋物种的协同作用仍然知之甚少。在这项研究中，在双壳软体动物Tegillarca granosa中研究了聚苯乙烯MP（直径500 nm和30μm）和舍曲林（Ser）的免疫毒性。结果表明，MP和Ser均显着抑制了T. granosa的免疫反应。另外，尽管Ser的毒性作用不受微型MP的影响，但是在Ser和纳米级MP之间观察到明显的协同免疫毒性作用，这表明两者之间的大小依赖性相互作用。为了进一步确定潜在的中毒机制，活性氧的细胞内含量，细胞凋亡状态，ATP含量，分析丙酮酸激酶活性，血浆皮质醇水平以及神经递质和细胞色素P450 1A1的体内浓度。还进行了转录组分析以揭示Ser和/或MPs暴露后的整体分子变化。获得的结果表明，纳米级MP的存在可通过（i）诱导血细胞凋亡并因此降低THC来增强Ser的免疫毒性。（ii）限制吞噬作用的能量供应；（iii）妨碍Ser的排毒。获得的结果表明，纳米级MP的存在可通过（i）诱导血细胞凋亡并因此降低THC来增强Ser的免疫毒性。（ii）限制吞噬作用的能量供应；（iii）妨碍Ser的排毒。获得的结果表明，纳米级MP的存在可通过（i）诱导血细胞凋亡并因此降低THC来增强Ser的免疫毒性。（ii）限制吞噬作用的能量供应；（iii）妨碍Ser的排毒。

更新日期：2020-04-21

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