We report an efficient growth factor delivering system based on polypeptide/heparin composite hydrogels for wound healing application. Linear and star-shaped poly(l-lysine) (l-PLL and s-PLL) were chosen due to not only their cationic characteristics, facilitating the efficient complexation of negatively charged heparin, but also the ease to tune the physical and mechanical properties of as-prepared hydrogels simply by varying polypeptide topology and chain length. The results showed that polymer topology can be an additional parameter to tune hydrogel properties. Our experimental data showed that these composite hydrogels exhibited low hemolytic activity and good cell compatibility as well as excellent antibacterial activity, making them ideal as wound dressing materials. Unlike other heparin-based hydrogels, these composite hydrogels with heparin densely deposited on the surface can increase the stabilization and concentration of growth factor, which can facilitate the healing process as confirmed by our in vivo animal model. We believe that these PLL/heparin composite hydrogels are promising wound dressing materials and may have potential applications in other biomedical fields.

我们报告了基于多肽/肝素复合水凝胶的伤口愈合应用有效的生长因子传递系统。线性和星形聚（l-赖氨酸）（l -PLL和s选择-PLL）的原因不仅在于它们的阳离子特性，有利于带负电荷的肝素的有效络合，而且还易于通过改变多肽的拓扑结构和链长来轻松调节已制备水凝胶的物理和机械性能。结果表明，聚合物拓扑结构可以作为调节水凝胶性能的另一个参数。我们的实验数据表明，这些复合水凝胶显示出低溶血活性，良好的细胞相容性以及出色的抗菌活性，使其成为伤口包扎材料的理想选择。与其他基于肝素的水凝胶不同，这些复合水凝胶具有紧密沉积在表面的肝素，可以增加生长因子的稳定性和浓度，从而可以促进愈合过程。体内动物模型。我们认为，这些PLL /肝素复合水凝胶是有前途的伤口敷料材料，可能在其他生物医学领域具有潜在的应用。