The reductive amination (RA) of 2-hydroxytetrahydropyran (2-HTHP) produced from biofurfural-derived dihydropyran provides a new efficient process for the clean synthesis of valuable 5-amino-1-pentanol (5-AP). Among various solid catalysts tested, the inexpensive Ni–Mg₃AlO_x catalysts derived from hydrotalcite precursors were found to be very active and selective, especially at Ni loadings above 20 wt %. A 85% total yield of 5-AP was obtained from dihydropyran on 40Ni–Mg₃AlO_x, the catalyst with the highest 2-HTHP RA activity among the Ni–Mg₃AlO_x catalysts, under mild conditions of 60 °C and 2 MPa H₂. Characterization results showed that the reducibility of the calcined NiO-Mg₃AlO_x samples increased with increasing Ni loading from 5 to 50 wt %, while the Ni⁰ crystallite sizes exhibited a minimum of 4.8 nm on 40Ni–Mg₃AlO_x after reduction in H₂ at 750 °C. The volcanic changes of 5-AP generation rate/yield with increasing Ni loading of the Ni–Mg₃AlO_x catalysts and with rising prereduction temperature of 30Ni–Mg₃AlO_x catalyst in 2-HTHP RA indicate that the balance of the reducibility and Ni⁰ particle size of the catalysts played an important role in obtaining high 5-AP yields. The 30Ni–Mg₃AlO_x catalyst showed a good stability in 2-HTHP RA examined in a continuous flow reactor over a 90 h time-on stream.

中文翻译：

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基于水滑石的Ni-Mg ₃ AlO _x催化剂上生物质衍生的二氢吡喃高效合成5-氨基-1-戊醇

由生物糠醛衍生的二氢吡喃生产的2-羟基四氢吡喃（2-HTHP）的还原胺化（RA）为清洁合成有价值的5-氨基-1-戊醇（5-AP）提供了一种新的有效方法。在各种测试的固体催化剂中，发现廉价的由水滑石前体衍生的Ni–Mg ₃ AlO _x催化剂具有很高的活性和选择性，特别是在Ni含量超过20 wt％时。从二氢吡喃在40Ni–Mg ₃ AlO _x上可以得到85％的5-AP ，这是Ni–Mg ₃ AlO _x催化剂中2-HTHP RA活性最高的催化剂，在60°C和2的温和条件下MPa H ₂。表征结果表明，煅烧后的NiO-Mg ₃ AlO _x样品的还原度随Ni含量从5 wt％增加到50 wt％而增加，而Ni ⁰晶粒尺寸在40Ni–Mg ₃ AlO _x还原后在4.8 nm处最小。在750°C下为H ₂。在2-HTHP RA中，随着Ni–Mg ₃ AlO _x催化剂的Ni负载增加以及30Ni–Mg ₃ AlO _x催化剂的预还原温度升高，5-AP生成速率/产率的火山变化表明，还原性和镍⁰催化剂的粒径对获得高5-AP收率起着重要作用。30Ni–Mg ₃ AlO _x催化剂在2-HTHP RA中在连续流反应器中经过90 h的运行时间进行了测试显示出良好的稳定性。