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In Vitro Cytocompatibility Assessment of Ti-Modified, Silicon-oxycarbide-Based, Polymer-Derived, Ceramic-Implantable Electrodes under Pacing Conditions
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-04-03 , DOI: 10.1021/acsami.0c01465 Pradeep Vallachira Warriam Sasikumar 1 , Eike Müller 2 , Pierrick Clement 3 , Jongmoon Jang 3 , Eirini Kakkava 4 , Giulia Panusa 4 , Demetri Psaltis 4 , Katharina Maniura-Weber 2 , Markus Rottmar 2 , Juergen Brugger 3 , Gurdial Blugan 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-04-03 , DOI: 10.1021/acsami.0c01465 Pradeep Vallachira Warriam Sasikumar 1 , Eike Müller 2 , Pierrick Clement 3 , Jongmoon Jang 3 , Eirini Kakkava 4 , Giulia Panusa 4 , Demetri Psaltis 4 , Katharina Maniura-Weber 2 , Markus Rottmar 2 , Juergen Brugger 3 , Gurdial Blugan 1
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Polymer-derived ceramics (PDC) have recently gained increased interest in the field of bioceramics. Among PDC’s, carbon-rich silicon oxycarbide ceramics (SiOC) possess good combined electrical and mechanical properties. Their durability in aggressive environments and proposed cytocompatibility makes them an attractive material for fabrication of bio-MEMS devices such as pacemaker electrodes. The aim of the present study is to demonstrate the remarkable mechanical and electrical properties, biological response of PDCs modified with titanium (Ti) and their potential for application as pacemaker electrodes. Therefore, a new type of SiOC modified with Ti fillers was synthesized via PDC route using a Pt-catalyzed hydrosilylation reaction. Preceramic green bodies were pyrolyzed at 1000 °C under an argon atmosphere to achieve amorphous ceramics. Electrical and mechanical characterization of SiCxO2(1–x)/TiOxCy ceramics revealed a maximum electrical conductivity of 10 S cm–1 and a flexural strength of maximal 1 GPa, which is acceptable for pacemaker applications. Ti incorporation is found to be beneficial for enhancing the electrical conductivity of SiOC ceramics and the conductivity values were increased with Ti doping and reached a maximum for the composition with 30 wt % Ti precursor. Cytocompatibility was demonstrated for the PDC SiOC ceramics as well as SiOC ceramics modified with Ti fillers. Cytocompatibility was also demonstrated for SiTiOC20 electrodes under pacing conditions by monitoring of cells in an in vitro 3D environment. Collectively, these data demonstrate the great potential of polymer-derived SiOC ceramics to be used as pacemaker electrodes.
中文翻译：
起搏条件下钛修饰的碳氧化硅基聚合物衍生的陶瓷可植入电极的体外细胞相容性评估
聚合物衍生的陶瓷（PDC）最近在生物陶瓷领域中引起了越来越多的兴趣。在PDC中，富碳的碳氧化硅陶瓷（SiOC）具有良好的电气和机械综合性能。它们在侵蚀性环境中的耐用性以及拟议的细胞相容性使它们成为制造诸如起搏器电极之类的生物MEMS设备的有吸引力的材料。本研究的目的是证明卓越的机械和电气性能，用钛（Ti）修饰的PDC的生物响应以及它们作为起搏器电极的潜力。因此，利用Pt催化的氢化硅烷化反应通过PDC途径合成了一种新型的Ti填料改性的SiOC。将陶瓷前生坯在氩气气氛下于1000°C进行热解，以获得无定形陶瓷。x O 2（1- x） / TiO x C y陶瓷的最大电导率为10 S cm –1和最大1 GPa的弯曲强度，这对于起搏器应用是可以接受的。发现掺入Ti有利于增强SiOC陶瓷的电导率，并且电导率值随着Ti掺杂而增加，并且对于具有30wt％的Ti前体的组合物达到最大值。证明了PDC SiOC陶瓷以及用Ti填料改性的SiOC陶瓷的细胞相容性。通过在体外3D环境中监控细胞，在起搏条件下还证明了SiTiOC20电极具有细胞相容性。总的来说，这些数据证明了将聚合物来源的SiOC陶瓷用作起搏器电极的巨大潜力。
更新日期：2020-04-06
中文翻译：
起搏条件下钛修饰的碳氧化硅基聚合物衍生的陶瓷可植入电极的体外细胞相容性评估
聚合物衍生的陶瓷（PDC）最近在生物陶瓷领域中引起了越来越多的兴趣。在PDC中，富碳的碳氧化硅陶瓷（SiOC）具有良好的电气和机械综合性能。它们在侵蚀性环境中的耐用性以及拟议的细胞相容性使它们成为制造诸如起搏器电极之类的生物MEMS设备的有吸引力的材料。本研究的目的是证明卓越的机械和电气性能，用钛（Ti）修饰的PDC的生物响应以及它们作为起搏器电极的潜力。因此，利用Pt催化的氢化硅烷化反应通过PDC途径合成了一种新型的Ti填料改性的SiOC。将陶瓷前生坯在氩气气氛下于1000°C进行热解，以获得无定形陶瓷。x O 2（1- x） / TiO x C y陶瓷的最大电导率为10 S cm –1和最大1 GPa的弯曲强度，这对于起搏器应用是可以接受的。发现掺入Ti有利于增强SiOC陶瓷的电导率，并且电导率值随着Ti掺杂而增加，并且对于具有30wt％的Ti前体的组合物达到最大值。证明了PDC SiOC陶瓷以及用Ti填料改性的SiOC陶瓷的细胞相容性。通过在体外3D环境中监控细胞，在起搏条件下还证明了SiTiOC20电极具有细胞相容性。总的来说，这些数据证明了将聚合物来源的SiOC陶瓷用作起搏器电极的巨大潜力。
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