Luminescent MOFs are ideal tools for sensing applications owing to the ability to trap analytes. A series of seven novel polymeric compounds i.e. [Cd(1,4-BDC) (Pro) (H₂O)]_∞, [Cd(1,4-BDC) (L-Trp) (H₂O)]_∞, [Cd(1,4-BDC) (L-Ala) (H₂O)]_∞, [Cd(1,4-BDC) (L-Phe) (H₂O)]_∞, [Cd(1,4-BDC) (L-Val) (H₂O)]_∞, [Cd(1,4-BDC) (L-Leu) (H₂O)]_∞, [Cd(1,4-BDC) (L-Arg) (H₂O)]_∞ were synthesized from layered structure Cd-MOF using the technique of postsynthetic modification. The postsynthetic modification was performed on metal center through the utilization of pure l-amino acids Proline(Pro), Tryptophan(Trp), Alanine(Ala), Phenylalanine (Phe). Valine(Val), Leucine(Leu) and Arginine (Arg). The post synthetically modified compounds were characterized by FTIR, TGA, ¹H NMR, Elemental analysis, PXRD and UV–visible spectroscopy. Luminescence properties were investigated in solid-state, which shows that all the novel compound has higher emission intensity as compared to parent MOF.