Certain pyridothienopyrimidine derivatives exhibit antiatheroscleorotic, antibacterial, antiviral, antidepressant, antidiabetic, antihypertensive, anticancer, antihistaminic, antiallergic, anti-inflammatory, spasmolytic, analgesic, and neurotropic activities. 4-Hydrazino-7,9-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine (1) is a reported pyridothienopyrimidine derivative. In the current study, (1) has been reacted with different reagents to obtain 12 new pyridothienopyrimidine derivatives. The newly synthesized five-membered heterocyclic rings incorporated with pyridothienopyrimidines have been screened for their antibacterial activities. The results encourage further studies on other possible biological activities.

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吡啶并吡啶并嘧啶并入的五元杂环的合成及抑菌活性

某些吡啶并吡啶并嘧啶衍生物显示出抗动脉粥样硬化，抗菌，抗病毒，抗抑郁，抗糖尿病，抗高血压，抗癌，抗组胺，抗过敏，抗炎，解痉，镇痛和神经活性。据报道，4-羟基-7,9-二甲基吡啶并[3'，2'：4,5]噻吩并[3,2- d ]嘧啶（1）是吡啶并吡啶并嘧啶的衍生物。在当前的研究中，（1）已经与不同的试剂反应以获得12个新的吡啶并噻吩并嘧啶衍生物。已经筛选了新合成的与吡啶并噻吩并嘧啶并入的五元杂环的抗菌活性。结果鼓励对其他可能的生物活性进行进一步的研究。