A one-pot synthesis of multifunctional Bi2S3 nanoparticles and the construction of core-shell Bi2S3@Ce6-CeO2 nanocomposites for NIR-triggered phototherapy.,Journal of Materials Chemistry B

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A one-pot synthesis of multifunctional Bi2S3 nanoparticles and the construction of core-shell Bi2S3@Ce6-CeO2 nanocomposites for NIR-triggered phototherapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-14 , DOI: 10.1039/d0tb00080a
Lingwan Zeng ₁ , Huan Zhao ₁ , Yuda Zhu ₁ , Suping Chen ₁ , Yusheng Zhang ₁ , Dan Wei ₁ , Jing Sun ₁ , Hongsong Fan ₁

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As a direct thin band gap n-type semiconductor, bismuth sulfide (Bi2S3) nanomaterials possess great near-infrared (NIR)-triggered photothermal effects, photoacoustic (PA) and computed tomography (CT) imaging properties. Hence, Bi2S3 nanomaterials have become a research focal point in multiple domains, such as the construction of NIR-triggered nanosystems for cancer therapy. In this study, through a simple one-pot synthesis with the assistance of EDTA-2Na, we first obtained monodispersed spherical Bi2S3 of uniform particle sizes with fascinating photothermal and PA/CT imaging properties. Based on this, we introduced the photosensitizer Ce6 with photodynamic property and CeO2 with the O2-evolving characteristic, and thus designed a core-shell structure of the Bi2S3@Ce6-CeO2 nanocomposites (Bi2S3@Ce6-CeO2 NCs). The as-received Bi2S3@Ce6-CeO2 NCs exhibited a remarkable synergetic photothermal and photodynamic therapeutic effect both in vitro and in vivo, demonstrating its promising potential for cancer treatments. In the long term, the multifunctional PA/CT properties of both Bi2S3 NPs and Bi2S3@Ce6-CeO2 NCs in this study also supply a novel Bi2S3-based platform for constructing integrated diagnosis and treatment platforms.

中文翻译：

一锅合成多功能Bi2S3纳米粒子和核壳Bi2S3 @ Ce6-CeO2纳米复合材料的构建，用于近红外触发的光疗。

作为直接的窄带隙n型半导体，硫化铋（Bi2S3）纳米材料具有很大的近红外（NIR）触发光热效应，光声（PA）和计算机断层扫描（CT）成像特性。因此，Bi2S3纳米材料已成为多个领域的研究重点，例如用于癌症治疗的NIR触发纳米系统的构建。在这项研究中，通过EDTA-2Na的简单一锅合成，我们首先获得了粒径均匀，具有令人着迷的光热和PA / CT成像特性的单分散球形Bi2S3。在此基础上，我们引入了具有光动力学性质的光敏剂Ce6和具有O2释放特性的CeO2，从而设计了Bi2S3 @ Ce6-CeO2纳米复合材料（Bi2S3 @ Ce6-CeO2 NCs）的核壳结构。Bi2S3 @ Ce6-CeO2 NCs在体外和体内均表现出显着的协同光热和光动力治疗效果，证明了其在癌症治疗中的潜力。从长远来看，这项研究中Bi2S3 NP和Bi2S3 @ Ce6-CeO2 NC的多功能PA / CT特性也为构建综合的诊断和治疗平台提供了一个新颖的基于Bi2S3的平台。

更新日期：2020-03-20

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