量化气雾剂成分对总氧化电位的协同，加性和拮抗作用。,Chemosphere

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量化气雾剂成分对总氧化电位的协同，加性和拮抗作用。
Chemosphere ( IF 8.1 ) Pub Date : 2020-03-20 , DOI: 10.1016/j.chemosphere.2020.126573
Huibin Guo ₁ , Haiyan Fu ₁ , Lei Jin ₁ , Sijing Huang ₂ , Xiang Li ₃

Affiliation

基于相互作用的氧化电位（OPint）表示通过包含PM组分之间的二元混合物信息来预测与线性可加性不同的二元混合物效应。这项工作的目的是对二元PM成分的可能协同或拮抗可能性进行可靠的估计，并量化组合效应。我们首先根据DTT消耗率和AA消耗评估了PM组件在生成OP中的相互作用。我们从标准溶液序列（从0.005到10μM）开始，包括醌（PQ，1,2-NQ和1,4-NQ）和金属（Cu，Mn和Fe）。金属之间的相互作用是DTT消耗中的拮抗作用。铜与PQ表现出拮抗作用，但与1,2-NQ和1,4-NQ加成。Mn与1协同作用 DTT消耗中的4-NQ，但与PQ（CPQ <2.5μM）和1,4-NQ（CPQ <2μM）相反。在所研究的浓度范围（0.01至5μM）中，Fe与醌具有协同作用。最后，与使用简单加法的经典计算方法相比，在交互作用量（M = 5）的基础上应用温和的方法会导致1-17％的环境风险。这项工作重点介绍了一种新方法，该方法可以量化PM组件中金属和醌之间的相互作用，并分摊组件对PM OP的贡献。与使用简单加法的经典计算方法相比，在交互作用量（M = 5）的基础上，导致较高的环境风险1-17％。这项工作重点介绍了一种新方法，该方法可以量化PM组件中金属和醌之间的相互作用，并分摊组件对PM OP的贡献。与使用简单加法的经典计算方法相比，在交互作用量（M = 5）的基础上，导致较高的环境风险1-17％。这项工作重点介绍了一种新方法，该方法可以量化PM组件中金属和醌之间的相互作用，并分摊组件对PM OP的贡献。

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Quantification of synergistic, additive and antagonistic effects of aerosol components on total oxidative potential.

The interaction-based oxidative potential (OPint) represents the prediction of binary mixture effects distinguishing from linear additivity by including information on binary mixtures among PM components. The objective of this work is to develope a reliable estimate on the possible synergistic or antagonistic possibility of binary PM components and to quantify the combined effect. We firstly assessed the interactions among PM components in generating the OP based on DTT consumption rate and AA depletion. We started with the standard solution sequence (from 0.005 to 10 μM), including quinones (PQ, 1,2-NQ, and 1,4-NQ) and metals (Cu, Mn, and Fe). The interactions between metals were antagonistic interactions in DTT consumption. Cu showed antagonistic interaction with PQ, but additive with 1,2-NQ and 1,4-NQ. Mn interacted synergistically with 1,4-NQ in DTT consumption but antagonistically with PQ (where CPQ < 2.5 μM) and 1,4-NQ (where CPQ < 2 μM). Fe showed synergistic with quinones in investigated concentration range (from 0.01 to 5 μM). Finally, applying a moderate approach, on the basis of interaction magnitude (M = 5), resulted in 1-17% higher environmental risks, compared with the classical calculation method using simple addition. This work highlights a new approach to quantify the interaction effects between metals and quinones in PM components, and apportioning the components' contributions for PM OP.

更新日期：2020-03-20

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