Natural Oral Anticancer Medication in Small Ethanol Nanosomes Coated with a Natural Alkaline Polysaccharide,ACS Applied Materials & Interfaces

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Natural Oral Anticancer Medication in Small Ethanol Nanosomes Coated with a Natural Alkaline Polysaccharide
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-03-30 , DOI: 10.1021/acsami.0c02788
Jing Zhao ₁ , Yuan Li ₁ , Dan He ₁ , Xueyuan Hu ₁ , Kailing Li ₁ , Qiang Yang ₁ , Chunshu Fang ₂ , Cailing Zhong ₁ , Jie Yang ₁ , Qunyou Tan ₂ , Jingqing Zhang ₁

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Oral medication is the most acceptable therapy to treat chronic diseases. Natural drugs and excipients have unique advantages, such as low cost and high safety. We first investigated modified ethanol nanosomes for tumor treatment via oral administration. We loaded curcumin (CM) into small ethanol nanosomes coated with the natural alkaline polysaccharide chitosan (CCSET) for increased absorption and bioavailability and enhanced efficacy against small cell lung cancer (SCLC). Compared to CM and noncoated ethanol nanosomes, CCSETs exhibited superior physicochemical, in vitro–in vivo kinetic, and absorptive properties and treatment efficacy at the cellular and animal levels. The interaction of CM and serum albumin (the quantitative binding force) was analyzed. The bioavailability of CCSET increased by 11.84-fold and the tumor growth inhibition rate increased markedly compared to CM. We first confirmed the effect of CM on SCLC stem cells, and CCSET greatly enhanced this action. We first reported that CM had an antitumor effect on SCLC at the animal level and that CCSET enhanced this effect. Natural alkaline polysaccharide-coated small ethanol nanosomes delivering natural medicine may be a potential oral anticancer strategy.

中文翻译：

天然碱性多糖包被的乙醇纳米小颗粒中的天然口服抗癌药物

口服药物是治疗慢性疾病最可接受的疗法。天然药物和赋形剂具有独特的优势，例如低成本和高安全性。我们首先研究了通过口服给药用于肿瘤治疗的修饰乙醇纳米体。我们将姜黄素（CM）加载到涂有天然碱性多糖壳聚糖（CCSET）的小型乙醇纳米脂质体中，以增加吸收和生物利用度，并增强抗小细胞肺癌（SCLC）的功效。与CM和未包被的乙醇纳米颗粒相比，CCSET在体外–体内表现出优异的理化性质在细胞和动物水平的动力学，吸收特性和治疗功效。分析了CM与血清白蛋白的相互作用（定量结合力）。与CM相比，CCSET的生物利用度提高了11.84倍，肿瘤生长抑制率显着提高。我们首先证实了CM对SCLC干细胞的作用，而CCSET大大增强了这种作用。我们首先报道了CM在动物水平上对SCLC有抗肿瘤作用，而CCSET增强了这种作用。提供天然药物的天然碱性多糖涂层小乙醇纳米小体可能是潜在的口服抗癌策略。

更新日期：2020-03-30

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