Abstract Corn fiber gum (CFG)-soybean protein isolate (SPI) double network (DN) hydrogels, with varied concentrations of CFG, were fabricated at room temperature in order to develop a biocompatible vehicle for the oral administration of thermosensitive bioactive compounds. Riboflavin (vitamin B2) was encapsulated in the gel as a model bioactive compound. The compound release properties of these DN hydrogels were investigated in simulated gastric and simulated intestinal fluids (SGF and SIF). DN hydrogels with 0.25% of CFG were found to be the most desirable of those assayed for the oral administration of bioactive compounds. The results of low-field nuclear magnetic resonance (LF-NMR) relaxometry measurement showed that the pH-responsive DN hydrogels exhibited low swelling ratio in the SGF but larger swelling ratio in the SIF. The results of degree of proteolysis and scanning electron microscopy (SEM) showed that significant release of riboflavin from DN hydrogels in the SIF was due to large swelling, CFG matrix erosion and the proteolysis of SPI. The release mechanisms of riboflavin through the DN hydrogels in the simulated intestinal fluid followed non-Fickian diffusion based on Peppas' semi-empirical equation.

中文翻译：

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玉米纤维胶-大豆分离蛋白双网络水凝胶作为热敏生物活性化合物的口服载体

摘要 在室温下制备了具有不同浓度 CFG 的玉米纤维胶 (CFG)-大豆分离蛋白 (SPI) 双网络 (DN) 水凝胶，以开发一种用于口服热敏生物活性化合物的生物相容性载体。核黄素（维生素 B2）被封装在凝胶中作为模型生物活性化合物。在模拟胃液和模拟肠液（SGF 和 SIF）中研究了这些 DN 水凝胶的化合物释放特性。发现含有 0.25% CFG 的 DN 水凝胶是最适合口服生物活性化合物的水凝胶。低场核磁共振 (LF-NMR) 弛豫测量结果表明，pH 响应 DN 水凝胶在 SGF 中表现出较低的溶胀率，但在 SIF 中表现出较大的溶胀率。蛋白水解程度和扫描电子显微镜 (SEM) 的结果表明，SIF 中 DN 水凝胶中核黄素的显着释放是由于大溶胀、CFG 基质侵蚀和 SPI 的蛋白水解。核黄素通过 DN 水凝胶在模拟肠液中的释放机制遵循基于 Peppas 半经验方程的非 Fickian 扩散。