Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability.,ChemBioChem

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Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-17 , DOI: 10.1002/cbic.202000009
Ander Maguregui ₁ , Hiroshi Abe ₂

Affiliation

To overcome the delivery and cell uptake hurdle to siRNA therapeutics, modifications have been made to improve in‐vivo delivery through numerous methods. Functional group modifications on ribose rings, alterations in phosphate backbone linkage, and conjugation of GalNAc, lipid and disulfide ligands to the siRNA duplex are all potential contributors to improving current gene therapies.