当前位置:
X-MOL 学术
›
Eur. J. Med. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
p62 as a therapeutic target for tumor
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.ejmech.2020.112231 Mengmin Tao , Tian Liu , Qidong You , Zhengyu Jiang
中文翻译:
p62作为肿瘤的治疗靶标
更新日期:2020-03-19
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.ejmech.2020.112231 Mengmin Tao , Tian Liu , Qidong You , Zhengyu Jiang
p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis.
中文翻译:
p62作为肿瘤的治疗靶标
p62 / SQSTM1(以下称为p62)是一种压力诱导型细胞蛋白,可与多种信号蛋白相互作用以调节多种细胞功能。越来越多的证据支持p62在肿瘤发生中的关键作用,p62可能成为肿瘤的治疗靶标。在这篇综述中,我们总结了p62结构域的生物学功能,报道的靶向p62的生物活性分子以及p62与肿瘤发生之间的关系。