In achondroplasia, lumbar spinal stenosis arises from congenital dysplasia and acquired degenerative changes. We here aimed to describe the changes of the lumbar spinal canal and intervertebral disc in adults. We included 18 adults (age ≥ 18 years) with achondroplasia and lumbar spinal stenosis. Radiographs were used to analyze spinal-pelvic angles. Antero-posterior diameter of the spinal canal and the grade of disc degeneration were measured by MRI. Antero-posterior diameters of the spinal canal differed by spinal level (P < 0.05), with lower values observed at T12-L1, L1-2 and L2-3. Degrees of disc degeneration differed by intervertebral level, with higher degrees observed at L1-2, L2-3 and L3-4. A significant correlation was found between disc degeneration and thoraco-lumbar kyphosis at L2-3, between antero-posterior diameter of the spinal canal and lumbar lordosis at T12-L1 and L2-3, and between antero-posterior diameter of the spinal canal and thoraco-lumbar kyphosis at L1-2. Unlike the general population, spinal stenosis and disc degeneration involve the upper part of the lumbar spine in adults with achondroplasia, associated with thoraco-lumbar kyphosis and loss of lumbar lordosis.

在软骨发育不全中，腰椎管狭窄是由先天性发育不良和后天性退行性变化引起的。我们此处旨在描述成人腰椎管和椎间盘的变化。我们纳入了18名成年人（≥18岁）患有软骨发育不全和腰椎管狭窄症。放射线照片用于分析脊柱骨盆角度。MRI测量椎管的前后直径和椎间盘退变的程度。椎管的前后径因脊柱水平而异（P <0.05），在T12-L1，L1-2和L2-3处观察到较小的值。椎间盘退变的程度因椎间盘水平而异，在L1-2，L2-3和L3-4处观察到较高的程度。发现在L2-3椎间盘退变与胸腰椎后凸畸形之间存在显着相关性，T12-L1和L2-3处椎管前后径与腰椎前凸之间以及L1-2处在椎管前后径与胸腰椎后凸畸形之间。与普通人群不同，脊椎狭窄和椎间盘退变涉及患有软骨发育不全的成年人的腰椎上部，与胸腰椎后凸畸形和腰椎前凸丢失有关。