Polycyclic spiroindolines are the basic skeletons of large families of indole alkaloids that exhibit a broad spectrum of biological and pharmacological activities. The past seven years have seen impressive developments in the construction of polycyclic spiroindolines enabled by 3-(2-isocyanoethyl)indole-based cascade reactions. We herein give a brief summary on this evolution and highlight our contributions in this field. 1 Introduction 2 Cascade Reactions Involving Nitrilium Ion Intermediates 3 Cascade Reactions Involving Ketenimine Intermediates 4 Conclusion and Outlook

中文翻译：

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3-(2-Isocyanoethyl)indole：多环螺二氢吲哚合成的多功能试剂

多环螺二氢吲哚是吲哚生物碱大家族的基本骨架，具有广泛的生物和药理活性。在过去的七年中，通过基于 3-（2-异氰乙基）吲哚的级联反应构建多环螺二氢吲哚的研究取得了令人瞩目的进展。我们在此简要总结了这一演变，并强调了我们在该领域的贡献。1 引言 2 涉及腈离子中间体的级联反应 3 涉及酮亚胺中间体的级联反应 4 结论和展望