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Parapapillary atrophy and changes in the optic nerve head and posterior pole in high myopia.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-03-12 , DOI: 10.1038/s41598-020-61485-2 Mi Sun Sung 1 , Hwan Heo 1 , Helong Piao 1 , Yue Guo 1 , Sang Woo Park 1
Scientific Reports ( IF 3.8 ) Pub Date : 2020-03-12 , DOI: 10.1038/s41598-020-61485-2 Mi Sun Sung 1 , Hwan Heo 1 , Helong Piao 1 , Yue Guo 1 , Sang Woo Park 1
Affiliation
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We investigated the relationship between microstructure of β-parapapillary atrophy (β-PPA) and morphologic features of optic nerve head (ONH) and posterior pole in highly myopic eyes. Eighty-nine highly myopic eyes were included in this study. Bruch's membrane opening (BMO) area, lamina cribrosa (LC) thickness, anterior laminar depth, peripapillary and subfoveal choroidal thickness (CT), macular Bruch's membrane (BM) length, and width of β-PPA with and without Bruch's membrane (PPA+BM and PPA-BM) were evaluated. The mean age and axial length of the included subjects were 26.88 ± 2.44 years and 27.03 ± 0.88 mm, respectively. The width of PPA-BM was larger with increasing BMO area (P = 0.001), whereas the BMO area was not associated with the width of PPA+BM. The large PPA+BM was significantly related to a thinner LC (P = 0.003), deeper anterior lamina surface (P < 0.001), longer macular BM length (P = 0.008), and thinner temporal peripapillary CT (P = 0.034). We found that the morphologic features of the ONH and posterior pole in highly myopic eyes were different based on the microstructure of β-PPA. Whether these features are linked to the development of glaucoma in myopic eyes should be investigated in future studies.
中文翻译：
高度近视眼的乳头旁萎缩和视神经头及后极的变化。
我们研究了高度近视眼中β-乳头旁萎缩（β-PPA）的微观结构与视神经乳头（ONH）和后极形态特征之间的关系。该研究包括八十九只高度近视的眼睛。Bruch的膜开口（BMO）区域，筛板（LC）厚度，前层深度，乳头周围和凹下脉络膜厚度（CT），黄斑Bruch膜（BM）长度以及有无Bruch膜（PPA +）的β-PPA宽度对BM和PPA-BM进行了评估。纳入受试者的平均年龄和轴向长度分别为26.88±2.44岁和27.03±0.88 mm。PMO-BM的宽度随BMO面积的增加而增大（P = 0.001），而BMO面积与PPA + BM的宽度无关。PPA + BM较大与LC较薄有关（P = 0.003），较厚的前椎板表面（P <0.001），较长的黄斑BM长度（P = 0.008）和较薄的颞周乳头CT（P = 0.034）。我们发现，根据β-PPA的微观结构，高度近视眼的ONH和后极的形态特征有所不同。这些特征是否与近视眼青光眼的发展有关，应在以后的研究中进行研究。
更新日期：2020-03-12
中文翻译：
高度近视眼的乳头旁萎缩和视神经头及后极的变化。
我们研究了高度近视眼中β-乳头旁萎缩（β-PPA）的微观结构与视神经乳头（ONH）和后极形态特征之间的关系。该研究包括八十九只高度近视的眼睛。Bruch的膜开口（BMO）区域，筛板（LC）厚度，前层深度，乳头周围和凹下脉络膜厚度（CT），黄斑Bruch膜（BM）长度以及有无Bruch膜（PPA +）的β-PPA宽度对BM和PPA-BM进行了评估。纳入受试者的平均年龄和轴向长度分别为26.88±2.44岁和27.03±0.88 mm。PMO-BM的宽度随BMO面积的增加而增大（P = 0.001），而BMO面积与PPA + BM的宽度无关。PPA + BM较大与LC较薄有关（P = 0.003），较厚的前椎板表面（P <0.001），较长的黄斑BM长度（P = 0.008）和较薄的颞周乳头CT（P = 0.034）。我们发现，根据β-PPA的微观结构，高度近视眼的ONH和后极的形态特征有所不同。这些特征是否与近视眼青光眼的发展有关，应在以后的研究中进行研究。
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