衰老的ECM衰老路径：成分和修饰剂。,The FEBS Journal

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衰老的ECM衰老路径：成分和修饰剂。
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-03-07 , DOI: 10.1111/febs.15282
Naama Levi ₁ , Nurit Papismadov ₁ , Inna Solomonov ₂ , Irit Sagi ₂ , Valery Krizhanovsky ₁

Affiliation

细胞外基质（ECM）是所有器官和组织中的关键非细胞成分。它由大量蛋白质组成，包括胶原蛋白，糖蛋白（GP）和ECM相关蛋白，这些蛋白显示出生化和生物物理功能的多样性。ECM在正常的组织生理和病理条件下都是动态的。与ECM成分表达和ECM重塑酶分泌变化相关的一种细胞现象是细胞衰老。它代表各种形式的应激在增殖细胞中诱导的细胞周期停滞的稳定状态。短期诱导衰老对于抑制肿瘤和修复组织至关重要。但是，组织中长期存在衰老细胞可能对促进组织损伤和衰老具有有害作用。最新，关于ECM和衰老细胞之间相互作用的知识不足。由于ECM的变化在存在衰老细胞的许多生理和病理条件下发生，因此有必要更好地了解ECM-衰老相互作用。在这里，我们将回顾不同ECM组件的功能，并讨论有关它们在衰老细胞中的调控及其对衰老状态的影响的当前知识。

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The ECM path of senescence in aging: components and modifiers.

The extracellular matrix (ECM) is a key noncellular component in all organs and tissues. It is composed of a large number of proteins including collagens, glycoproteins (GP), and ECM‐associated proteins, which show diversity of biochemical and biophysical functions. The ECM is dynamic both in normal physiology of tissues and under pathological conditions. One cellular phenomenon associated with changes in both ECM components expression and in ECM remodeling enzymes secretion is cellular senescence. It represents a stable state form of cell cycle arrest induced in proliferating cells by various forms of stress. Short‐term induction of senescence is essential for tumor suppression and tissue repair. However, long‐term presence of senescent cells in tissues may have a detrimental role in promoting tissue damage and aging. Up to date, there is insufficient knowledge about the interplay between the ECM and senescence cells. Since changes in the ECM occur in many physiological and pathological conditions in which senescent cells are present, a better understanding of ECM‐senescence interactions is necessary. Here, we will review the functions of the different ECM components and will discuss the current knowledge about their regulation in senescent cells and their influence on the senescence state.

更新日期：2020-03-07

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