Long-term bone healing/adaptation after a dental implant treatment starts with diffusion of mesenchymal stem cells to the wounded region and their subsequent differentiation. The healing phase is followed by the bone-remodeling phase. In this work, a mechano-regulatory cellular differentiation model was used to simulate tissue healing around an immediately loaded dental implant. All tissue types were modeled as poroelastic in the healing phase. Material properties of the healing region were updated after each loading cycle for 30 cycles (days). The tissue distribution in the healed state was then used as the initial condition for the remodeling phase during which regions healed into bone adapt their apparent density with respect to a homeostatic remodeling stimulus. The short- (bone healing) and long-term (bone remodeling) effects of initial implant micromotion during the healing phase were studied. Development of soft tissue was observed both in the coronal region due to high fluid velocity, and on the vertical sides of the healing-gap due to high shear stress. In cases with small implant micromotion, tissue between the implant threads differentiated into bone during the healing phase but resorbed during remodeling. In cases with large implant micromotion, higher percentage of the healing region differentiated into soft tissue resulting in smaller volume of bone tissue available for remodeling. However, the remaining bone region developed higher density bone tissue. It was concluded that an optimal range of initial implant micromotion could be designed for a specific patient in order to achieve the desired long-term functional properties.

牙种植体治疗后的长期骨愈合/适应始于间充质干细胞向伤口区域的扩散及其随后的分化。愈合阶段之后是骨骼重塑阶段。在这项工作中，使用机械调节的细胞分化模型来模拟立即加载的牙科植入物周围的组织愈合。在康复阶段，所有组织类型均被建模为多孔弹性的。在每个加载周期持续30个周期（天）后，更新愈合区域的材料属性。然后，将处于愈合状态的组织分布用作重塑阶段的初始条件，在此阶段中，被愈合到骨骼中的区域针对稳态重塑刺激调整其表观密度。研究了在愈合阶段初始植入物微运动的短期（骨愈合）和长期（骨重塑）效果。由于高流速在冠状区域和由于高剪切应力在愈合间隙的垂直侧均观察到软组织的发育。在植入物微动较小的情况下，植入物线之间的组织在愈合阶段分化为骨骼，但在重塑过程中被吸收。在植入物微动较大的情况下，较高百分比的愈合区域分化为软组织，从而导致较小的骨组织体积可用于重塑。然而，剩余的骨区域发展出更高密度的骨组织。