We synthesized a double-walled knotted cage from a flexible tripodal ligand. The characteristic double-walled structure provided a unique adaptive behavior of the cavity upon inclusion of organic molecules, which was evidenced by NMR and X-ray measurements. The semi-flexible host framework, restricted by the knotted topology, enabled kinetic molecular recognition revealing the sequential binding of two different guests from their mixture.

中文翻译：

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用于客体自适应分子识别的双壁打结笼

我们从灵活的三足配体合成了一个双壁打结笼。特征性的双壁结构在包含有机分子时提供了独特的空腔自适应行为，核磁共振和 X 射线测量证明了这一点。受打结拓扑限制的半柔性宿主框架使动力学分子识别成为可能，揭示了两种不同客体从其混合物中的顺序结合。