Tetrapod Polymersomes,Journal of the American Chemical Society

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Tetrapod Polymersomes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-03-09 , DOI: 10.1021/jacs.9b12925
Jiangang Xiao _{1,

2} , Jianzhong Du _{1,

2}

Affiliation

Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetrapod polymersome that is evolved via precisely controlled fusion of four traditional spherical polymersomes that are self-assembled from poly(ethylene oxide)113-block-poly[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl methacrylate61-statistic-2-(diethylamino)ethyl methacrylate23] [PEO113-b-P(TBA61-stat-DEA23)] in DMF/water at lower water content (Cw). To unravel the secret behind the tetrapod polymersomes, a series of block copolymers with various comonomer types and degrees of polymerization were synthesized. PEO113-b-PTBA80 self-assembles into spherical micelles in DMF/water, and the subsequent evolution into tripod and multipod micelles, and finally micelle clusters upon increasing Cw suggests that the TBA is a 'pro-fusion' component that facili-tates the fusion due to its providential hydrophobicity and chain mobility. When one fourth of TBA of PEO113-b-PTBA80 is substi-tuted by DEA, spherical polymersomes of PEO113-b-P(TBA61-stat-DEA23) are born in DMF/water, and then fused into dipod, tripod (Cw = 95%), and finally tetrapod polymersomes (Cw = 100%) upon increasing Cw, suggesting that the DEA is not only a promotor of hollow pods, but also an 'anti-fusion' component that can compromise with 'pro-fusion' force for its high chain mobility. Either tetrapod polymersome or micelle cluster is a matter of balance between 'pro-fusion' and 'anti-fusion' forces. Overall, we provide a fresh insight for creating tetrapod polymersomes as well as other higher-order structures with precisely defined spatial compartments.

中文翻译：

四足聚合物

聚合物囊泡等中空纳米粒子在许多领域具有广阔的应用前景。然而，具有精确控制空间隔室的高阶聚合物囊泡的设计和构建仍然非常具有挑战性。在此，我们报告了一种独特的四足体聚合物体，它是通过四种传统球形聚合物体的精确控制融合进化而来的，这些球形聚合物体由聚（环氧乙烷）113-嵌段-聚[4-(4,4,5,5-四甲基- 1,3,2-二氧杂硼烷-2-基)苄基甲基丙烯酸酯61-statistic-2-(二乙基氨基)乙基甲基丙烯酸酯23][PEO113-bP(TBA61-stat-DEA23)]在DMF/水中，在较低的水含量(Cw)中。为了揭开四足聚合物体背后的秘密，合成了一系列具有各种共聚单体类型和聚合度的嵌段共聚物。PEO113-b-PTBA80 在 DMF/水中自组装成球形胶束，随后演变为三脚架和多脚架胶束，最后随着 Cw 增加而形成胶束簇表明 TBA 是一种“亲融合”成分，由于其天生的疏水性和链流动性，可促进融合。当PEO113-b-PTBA80的TBA的四分之一被DEA取代时，PEO113-bP(TBA61-stat-DEA23)的球形聚合物囊泡在DMF/水中诞生，然后融合成双脚架、三脚架(Cw = 95%) )，最后是增加 Cw 后的四足聚合物体 (Cw = 100%)，这表明 DEA 不仅是空心豆荚的促进剂，而且还是一种“抗融合”成分，可以与“亲融合”力妥协高链流动性。四足聚合物体或胶束簇是“促融合”和“反融合”力之间的平衡问题。全面的，

更新日期：2020-03-09

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