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Polymer‐Based Porous Microcapsules as Bacterial Traps
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-03-04 , DOI: 10.1002/adfm.201908855
Rongcong Luo 1, 2 , Sadaf Pashapour 1, 2 , Oskar Staufer 1, 2 , Ilia Platzman 1, 2 , Joachim P. Spatz 1, 2, 3
Affiliation  

Exposure to live bacteria and accumulation of dead bacteria during bactericidal processes can cause bacterial infectious diseases, implant failure, and antibacterial surface deterioration. Microcapsules with asymmetrically distributed, funnel‐shaped pores, which are capable of capturing, retaining, and killing bacteria are developed, offering a solution to bacterial contamination in liquids. It is found that bacterial isolation inside microcapsules is mainly driven by the bacteria's own motility and the microcapsules' geometry. After entry into the microcapsule cavity, the bacteria are stably retained inside. The microcapsules shield surrounding cells from exposure to bacterial toxins, as demonstrated by the coculture of rat embryonic fibroblast cells with microcapsules loaded with live Escherichia coli. The microcapsules can be enhanced with a bactericidal coating covering only the interior cavity. This confines the bacteria‐killing process, thereby further increasing biocompatibility. The microcapsules may offer a viable bacteria combatant approach as a potentially advantageous method to eradicate bacterial contamination.

中文翻译:

聚合物基多孔微胶囊作为细菌陷阱

在杀菌过程中暴露于活细菌和死细菌的积累会导致细菌感染性疾病,植入失败以及抗菌表面变质。开发了具有不对称分布的漏斗形孔的微囊,它们能够捕获,保留和杀死细菌,从而为解决液体中的细菌污染提供了解决方案。发现微胶囊内部的细菌分离主要由细菌自身的运动性和微胶囊的几何形状驱动。进入微囊腔后,细菌被稳定地保留在内部。将大鼠胚胎成纤维细胞与载有活大肠杆菌的微胶囊共培养证明,微胶囊可保护周围的细胞免受细菌毒素的侵害。。可以通过仅覆盖内部空腔的杀菌涂层来增强微胶囊。这限制了细菌的杀灭过程,从而进一步提高了生物相容性。微胶囊可提供可行的细菌对抗方法,作为消除细菌污染的潜在有利方法。
更新日期:2020-04-21
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