2,2',4,4',5-Pentabromodiphenyl ether 在体外诱导 3T3-L1 和人类前脂肪细胞分化过程中的脂质积累。,Journal of Biochemical and Molecular Toxicology

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2,2',4,4',5-Pentabromodiphenyl ether 在体外诱导 3T3-L1 和人类前脂肪细胞分化过程中的脂质积累。
Journal of Biochemical and Molecular Toxicology ( IF 3.2 ) Pub Date : 2020-03-04 , DOI: 10.1002/jbt.22485
Laura E Armstrong ₁ , Stephen Akinbo ₁ , Angela L Slitt ₁

Affiliation

阻燃剂，特别是多溴二苯醚 (PBDE)，是广泛用于工业用途和家用材料的化合物。NHANES 数据表明，几乎所有美国人的血清中都含有微量的多溴二苯醚，与职业接触相关的水平甚至更高。众所周知，多溴二苯醚因其亲脂性和稳定性而在环境中具有生物累积性，更重要的是，它们已在人体脂肪组织中检测到。本研究检查了 PBDE 同源物 BDE-99（2,2',4,4',5-五溴二苯醚；0.2-20 μM）是否通过诱导脂质积累在体外增强小鼠和人类前脂肪细胞模型的脂肪生成. 3T3-L1 小鼠前脂肪细胞和人内脏前脂肪细胞在 BDE-99 处理后表现出增强的激素诱导的脂质积累。此外，BDE-99 (20 μM) 在未分化的人类前脂肪细胞中诱导前脂肪细胞分化和脂质发育。BDE-99 是人类脂肪组织中第二丰富的同源物，它增加了分化脂肪细胞中的总脂质，因此显示出在调节脂肪生成中的潜在作用。这需要更多的研究来进一步了解亲脂性持久污染物对脂肪组织稳态的影响。

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2,2',4,4',5-Pentabromodiphenyl ether induces lipid accumulation throughout differentiation in 3T3-L1 and human preadipocytes in vitro.

Flame retardants, specifically polybrominated diphenyl ethers (PBDEs), are chemical compounds widely used for industrial purposes and household materials. NHANES data indicate that nearly all Americans have trace amounts of PBDEs in serum, with even higher levels associated with occupational exposure. PBDEs are known to bioaccumulate in the environment due to their lipophilicity and stability, and more importantly, they have been detected in human adipose tissue. The present study examined whether the PBDE congener, BDE‐99 (2,2′,4,4′,5‐pentabromodiphenyl ether; 0.2‐20 μM), enhances the adipogenesis of mouse and human preadipocyte cell models in vitro via induced lipid accumulation. 3T3‐L1 mouse preadipocytes and human visceral preadipocytes demonstrated enhanced hormone‐induced lipid accumulation upon BDE‐99 treatment. In addition, BDE‐99 (20 μM) induced preadipocyte differentiation and lipid development in nondifferentiated human preadipocytes. BDE‐99, the second most abundant congener in human adipose tissue, increased total lipids in differentiating adipocytes and therefore showed a potential role in the regulation of adipogenesis. This warrants more research to further understand the impact of lipophilic persistent pollutants on adipose tissue homeostasis.

更新日期：2020-03-04

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