膳食黄芩苷锌补充剂可减轻氧化应激并增强脱氧雪腐镰刀菌烯醇攻击猪的营养吸收。,Current Drug Metabolism

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膳食黄芩苷锌补充剂可减轻氧化应激并增强脱氧雪腐镰刀菌烯醇攻击猪的营养吸收。
Current Drug Metabolism ( IF 2.1 ) Pub Date : 2020-06-30 , DOI: 10.2174/1389200221666200302124102
Andong Zha _{1,

2} , Zhijuan Cui ₁ , Ming Qi _{1,

2} , Simeng Liao _{1,

2} , Lixin Chen _{2,

3} , Peng Liao ₁ , Bie Tan ₁

Affiliation

背景：脱氧雪腐镰刀菌烯醇污染在全球范围内不断增加，给粮食安全带来了巨大挑战，并给畜牧业造成了巨大的经济损失。

目的：本研究旨在确定黄芩苷锌作为膳食补充剂对饲喂脱氧雪腐镰刀菌烯醇污染日粮的猪的保护作用。

方法：总共 40 头断奶猪（21 日龄；6.13 ± 0.42 kg 平均体重）被随机分配（10 头猪/组）到 4 种日粮处理：基础日粮（Con 组）、基础日粮 + 4 mg/kg DON （DON 组）、基础饮食 + 5 g/kg BZN（BZN 组）和基础饮食 + 5 g/kg BZN + 4 mg/kg DON（DBZN 组），持续 14 天。从每个处理中随机选择 7 头猪进行血液和组织取样。

结果：结果表明，接受 DON 攻击的仔猪的 ADG、ADFI 和 F/G 水平显着降低（p < 0.05）。BZN 补充日粮显着抑制了 DON 攻击仔猪空肠中 p-Nrf2、p-NF-kB 和 HO-1 的蛋白质表达（p < 0.05）。在肝脏中，DON 显着增加饲喂基础日粮的仔猪 P70S6K 和 HSP70 的 mRNA 表达，但显着降低饲喂 BZN 补充日粮的仔猪的 HO-1、NQO-1、NF-kB、AMPKα2 和 HSP70 的 mRNA 表达（p < 0.05）。日粮中添加 BZN 显着增加了断奶仔猪血清的 T-AOC 水平（p < 0.05）。在空肠中，日粮中添加 BZN 激活了仔猪 ZIP4 的 mRNA 表达（p < 0.05），

结论：BZN可以通过降低氧化应激和增强饲喂受DON污染日粮的猪的营养吸收来发挥保护作用。

"点击查看英文标题和摘要"

Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs.

Background: Deoxynivalenol contamination is increasing worldwide, presenting great challenges to food security and causing great economic losses in the livestock industry.

Objective: This study was conducted to determine the protective effect of baicalin zinc as a dietary supplement on pigs fed with a deoxynivalenol contaminated diet.

Methods: A total of 40 weaned pigs (21 d of age; 6.13 ± 0.42 kg average BW) were randomly assigned (10 pigs/group) to 4 dietary treatments: basal diet (Con group), basal diet + 4 mg/kg DON (DON group), basal diet + 5 g/kg BZN (BZN group), and basal diet + 5 g/kg BZN + 4 mg/kg DON (DBZN group) for a 14-d period. Seven randomly-selected pigs from each treatment were killed for blood and tissue sampling.

Results: The results showed that piglets challenged with DON exhibited significantly reduced levels of ADG, ADFI, and F/G (p < 0.05). BZN supplemented diets significantly suppressed the protein expression of p-Nrf2, p-NF-kB, and HO-1 in the jejunum of DON challenged piglets (p < 0.05). In liver, DON markedly increased the mRNA expression of P70S6K and HSP70 in piglets fed the basal diet, but significantly reduced that of HO-1, NQO-1, NF-kB, AMPKα2 and HSP70 in piglets fed the BZN supplemented diet (p < 0.05). Dietary supplementation with BZN markedly increased the T-AOC level of serum in weaned piglets (p < 0.05). In jejunum, dietary supplementation with BZN activated the mRNA expression of ZIP4 in piglets (p < 0.05), BZN supplementation significantly suppressed the activity of sucrose and increased the protein concentration in chyme (p < 0.05).

Conclusion: BZN can play a protective role by reducing oxidative stress and enhancing nutrient absorption in pigs fed DON-contaminated diets.

更新日期：2020-06-30

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