A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route for preparation of UDCA, most of the reaction steps have high conversions with average yields of 91%, and overall yield up to 59% (6 steps) from the plant-source BA. Especially in the last step of reduction and hydrolysis, there are five functional groups converted with calcd 97% per conversion in one-pot reaction. This promising route offers economical and efficient strategies for potential large-scale production of UDCA.

中文翻译：

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由植物来源的（20S）-21-羟基-20-甲基孕烷-4-烯-3-酮合成熊去氧胆酸。

通过廉价和可商购获得的bisnoralcohol（BA）的多次反应，开发了一种生产熊去氧胆酸（UDCA）的新型合成途径。研究并优化了关键反应条件，包括溶剂，碱和路线的反应温度。在制备UDCA的简单方法中，大多数反应步骤均具有很高的转化率，平均收率达91％，而植物来源BA的总收率高达59％（6个步骤）。特别是在还原和水解的最后一步中，一锅反应中有五个官能团的转化率约为每次转化率的97％。这一有前途的途径为潜在的UDCA大规模生产提供了经济有效的策略。