源自黄芪的黄芪甲苷IV：药理作用研究综述。,Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer

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源自黄芪的黄芪甲苷IV：药理作用研究综述。
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer Pub Date : 2019-12-18 , DOI: 10.1016/bs.apha.2019.08.002
Jianqin Zhang ₁ , Chuxuan Wu ₁ , Li Gao ₁ , Guanhua Du ₂ , Xuemei Qin ₁

Affiliation

由黄芪的根制成的煎剂被称为“黄芪”，被广泛用于中药中，用于治疗病毒和细菌感染，炎症以及癌症。黄芪甲苷IV（AS-IV）是黄芪水提取物中的主要化合物之一，是一种环烷型三萜糖苷化学物质。迄今为止，在细胞和动物模型中的许多研究表明，AS-IV在心血管，肺，肾和脑中具有有效的保护作用。基于过去几十年的研究，本综述系统地总结了AS-IV的药理作用，药代动力学和毒性。我们将详细分析AS-IV对神经保护，肝脏保护，抗癌和抗糖尿病的药理作用，这归因于其抗氧化剂，抗炎，抗凋亡特性，以及在增强免疫力，减弱癌细胞迁移和侵袭以及改善化疗药物化学敏感性方面的作用。此外，还详细介绍了AS-IV与其他中药或化学药物有效成分结合的最新进展。这些药理作用与多个信号通路相关，包括Raf-MEK-ERK通路，EGFR-Nrf2信号通路，Akt / PDE3B信号通路，AMPK信号通路，NF-κB信号通路，Nrf2抗氧化剂信号通路，PI3K / Akt / mTOR信号通路，PKC-α-ERK1/2-NF-κB通路，IL-11 / STAT3信号通路，Akt /GSK-3β/β-catenin通路，JNK / c-Jun / AP-1信号通路，PI3K / Akt /NF-κB途径，miRNA-34a / LDHA途径，Nox4 / Smad2途径，JNK途径和NF-kB /PPARγ途径。这篇综述将对黄芪甲苷IV在神经保护，肝脏保护，抗癌和抗糖尿病方面的药理作用有一个整体的了解。鉴于此，AS-IV将是用于治疗上述疾病的有效替代治疗剂。

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Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects.

Decoctions prepared from the roots of Astragali Radix are known as "Huangqi" and are widely used in traditional Chinese medicine for treatment of viral and bacterial infections, inflammation, as well as cancer. Astragaloside IV (AS-IV), one of the major compounds from the aqueous extract of Astragalus membranaceus, is a cycloartane-type triterpene glycoside chemical. To date, many studies in cellular and animal models have demonstrated that AS-IV possesses potent protective effects in cardiovascular, lung, kidney and brain. Based on studies over the past several decades, this review systematically summarizes the pharmacological effects, pharmacokinetics and the toxicity of AS-IV. We analyze in detail the pharmacological effects of AS-IV on neuroprotection, liver protection, anti-cancer and anti-diabetes, attributable to its antioxidant, anti-inflammatory, anti-apoptotic properties, and the roles in enhancement of immunity, attenuation of the migration and invasion of cancer cells and improvement of chemosensitivity of chemotherapy drugs. In addition, the latest developments in the combination of AS-IV and other active ingredients of traditional Chinese medicine or chemical drugs are detailed. These pharmacological effects are associated with multiple signaling pathways, including the Raf-MEK-ERK pathway, EGFR-Nrf2 signaling pathway, Akt/PDE3B signaling pathway, AMPK signaling pathway, NF-κB signaling pathway, Nrf2 antioxidant signaling pathways, PI3K/Akt/mTOR signaling pathway, PKC-α-ERK1/2-NF-κB pathway, IL-11/STAT3 signaling pathway, Akt/GSK-3β/β-catenin pathway, JNK/c-Jun/AP-1 signaling pathway, PI3K/Akt/NF-κB pathway, miRNA-34a/LDHA pathway, Nox4/Smad2 pathway, JNK pathway and NF-kB/PPARγ pathway. This review will provide an overall understanding of the pharmacological functions of astragaloside IV on neuroprotection, liver protection, anti-cancer and anti-diabetes. In light of this, AS-IV will be a potent alternative therapeutic agent for treatment of the above mentioned diseases.

更新日期：2019-12-18

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