Current Protein & Peptide Science ( IF 1.9 ) Pub Date : 2020-07-31 , DOI: 10.2174/1389203721666200219100216 Fei Xie 1 , Zhengqun Liu 1 , Ming Liu 1 , Liang Chen 1 , Wei Ding 2 , Hongfu Zhang 1
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Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid metabolism. A growing number of studies have shown that AAs are closely related to energy metabolism. This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity.
中文翻译：
氨基酸调节糖脂代谢并改变肠道微生物组成。
氨基酸（AAs）及其代谢产物调节机体生长，繁殖，免疫和新陈代谢所必需的关键代谢途径。已经确信代谢疾病与糖脂代谢紊乱密切相关。越来越多的研究表明，AA与能量代谢密切相关。这篇综述着重于氨基酸（精氨酸，支链氨基酸，谷氨酰胺）及其代谢产物（短链脂肪酸）通过调节PI3K / AKT / mTOR和AMPK信号通路以及GPCRs受体，减少肠道硬脂酸对糖脂代谢的影响。 /肥胖比率与肥胖有关。
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