健康黑人成人补充维生素 D3 的肥胖和功效。,Cancer Causes & Control

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健康黑人成人补充维生素 D3 的肥胖和功效。
Cancer Causes & Control ( IF 2.2 ) Pub Date : 2020-02-12 , DOI: 10.1007/s10552-020-01275-3
Hanseul Kim ₁ , Paulette Chandler ₂ , Kimmie Ng ₃ , JoAnn E Manson _{1,

2} , Edward Giovannucci _{1,

2,

4}

Affiliation

目的最近的临床试验结果表明，维生素 D 对癌症的疗效可能受体重指数的影响。由于抑制甲状旁腺激素 (PTH) 是维生素 D 功效的一项指标，我们研究了补充维生素 D3 的剂量在多大程度上抑制了肥胖和非肥胖个体的 PTH 水平。方法总共 328 名健康的非裔美国人被随机分为以下四组并接受 3 个月的治疗：安慰剂、1,000、2,000 或 4,000 IU/天的维生素 D3 补充剂。结果在参与者中，250 名进行 PTH 测量的个体被纳入分析。肥胖个体（n = 141）经历了从安慰剂到 1,000 IU/天补充维生素 D3 的 3 个月 PTH 急剧减少，但在 2,000 或 4,000 IU/天时没有进一步减少。对于非肥胖个体 (n = 109)，3 个月 PTH 的减少与增加维生素 D3 剂量大致呈线性关系。每天补充 2,000 至 4,000 IU 时，非肥胖和肥胖个体的 3 个月 25(OH) 维生素 D 水平均较高，但肥胖个体的 3 个月 PTH 水平仍高出约 10 pg/mL。结论我们的研究结果表明，即使以高剂量给药，过度肥胖也会导致对维生素 D 抑制 PTH 水平的功效产生抵抗。

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Obesity and efficacy of vitamin D3 supplementation in healthy black adults.

PURPOSE Results from recent clinical trials suggest that vitamin D efficacy against cancer may be influenced by body mass index. As suppression of parathyroid hormone (PTH) is one indicator of vitamin D efficacy, we examined to what extent doses of vitamin D3 supplementation suppress PTH levels in individuals with and without obesity. METHODS A total of 328 healthy African Americans were randomized into the following four groups and treated for 3 months: placebo, 1,000, 2,000, or 4,000 IU/day of vitamin D3 supplementation. RESULTS Among the participants, 250 individuals with PTH measurements were included in the analysis. Obese individuals (n = 141) experienced a steep reduction of 3-month PTH from placebo to 1,000 IU/day of vitamin D3 supplementation, but no further reduction at 2,000 or 4,000 IU/day. For non-obese individuals (n = 109), the reduction of 3-month PTH was approximately linear for increasing vitamin D3 doses. At supplementation of 2,000 to 4,000 IU/day, 3-month 25(OH)vitamin D levels were high in both non-obese and obese individuals, but the 3-month PTH levels remained about 10 pg/mL higher in individuals with obesity. CONCLUSION Our findings suggest that excess adiposity confers resistance to vitamin D efficacy in suppressing PTH levels, even when given at high doses.

更新日期：2020-04-13

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