肾上腺素与利多卡因混合在整形外科中的用途。,The Journal of Craniofacial Surgery

当前位置： X-MOL 学术 › J. Craniofacial Surg. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

肾上腺素与利多卡因混合在整形外科中的用途。
The Journal of Craniofacial Surgery ( IF 1.0 ) Pub Date : 2020-02-05 , DOI: 10.1097/scs.0000000000006156
Hun Kim ₁ , Kun Hwang ₁ , Seon Mi Yun ₁ , Dae Joong Kim ₂

Affiliation

整形外科医生通常给予皮下肾上腺素以减少术中失血。作者假设存在安全有效浓度的肾上腺素，用于血管收缩及其持续时间。本研究的目的是总结在整形外科领域中肾上腺素与利多卡因混合使用的现有文献。1903年，Braun报道肾上腺素延长了可卡因的局部麻醉作用。帕克-戴维斯公司开始销售可卡因和肾上腺素，以及将肾上腺素与新型合成局麻药联合使用。根据文献回顾，浓度为1：50,000至1：400,000的药物同样有效，与更稀的药物相比，具有更好的血管收缩作用解决方案。如果肾上腺素被进一步稀释，它的发作和达到血药浓度峰值的时间被延迟，并且作用时间缩短。当使用利多卡因而不使用肾上腺素时，麻醉时间与利多卡因浓度成反比地缩短。当利多卡因与肾上腺素一起使用时，麻醉时间与利多卡因浓度成比例地延长。在软组织中注射速度较慢的情况下，利多卡因的最大安全剂量约为3 mg / kg普通剂量，与肾上腺素混合时为7 mg / kg。利多卡因具有抗心律不齐的活性，因此可以保护心肌，这是在全身麻醉中渗入利多卡因与肾上腺素混合的基本原理。在整形外科中，皮下渗入肾上腺素-利多卡因溶液可减少术中失血。即使是全身麻醉

"点击查看英文标题和摘要"

Usage of Epinephrine Mixed With Lidocaine in Plastic Surgery.

Plastic surgeons commonly administer subcutaneous epinephrine to reduce intraoperative blood loss. The authors hypothesized that there are safe and effective concentration of epinephrine for vasoconstriction and their durations. The aim of this study is to summarize the existing literatures for the usage of epinephrine mixed with lidocaine in plastic surgical field.In 1903, Braun reported that adrenaline prolonged the local anesthetic effects of cocaine. The Parke-Davis Company began selling cocaine with adrenaline, as well as combining adrenaline with new synthetic local anesthetics.Based on a review of the literature, concentrations between 1:50,000 and 1:400,000 are equally effective and provide superior vasoconstriction compared with more dilute solutions. If epinephrine is further diluted, its onset and time to peak serum concentration are delayed, and its duration of action is shortened. When lidocaine is used without epinephrine, duration of anesthesia is shortened reverse proportionally to the lidocaine concentration. When lidocaine is used with epinephrine, duration of anesthesia is prolonged proportionally to the lidocaine concentration. With slow injection rate in the soft tissue, the maximum safe dose of lidocaine is approximately 3 mg/kg plain and 7 mg/kg when mixed with epinephrine. Lidocaine may protect the myocardium because of its antiarrhythmic activity, which is the rationale for infiltrating lidocaine mixed with epinephrine in general anesthesia.In plastic surgery, subcutaneous infiltration of epinephrine-lidocaine solution is performed to reduce intraoperative blood loss. Even in general anesthesia, infiltrating lidocaine mixed with epinephrine may protect the myocardium because of its antiarrhythmic activity.

更新日期：2020-02-05

点击分享查看原文

点击收藏

阅读更多本刊新发论文