A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective.,Journal of Cellular Physiology

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A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-02-04 , DOI: 10.1002/jcp.29616
Nazila Fathi Maroufi _{1,

2,

3} , Kouichi Hasegawa ₄ , Vahid Vahedian _{5,

6} , Saeed Nazari Soltan Ahmad ₃ , Amir Zarebkohan ₇ , Seyed Ali Miresmaeili Mazrakhondi ₈ , Vahid Hosseini _{3,

9} , Reza Rahbarghazi _{9,

10}

Affiliation

Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan.
Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University, Sari, Iran.
Clinical Laboratory Medicine Department, Rofeydeh Hospital University of Social Welfare and Rehabilitation Science, Tehran, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biology, Faculty of Basic Sciences, Yazd University, Yazd, Iran.
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Embryonic stem cells have potential differentiation ability into a large variety of cell lineages and proved to be an effective therapeutic modality. However, prolonged in vitro and ex‐vivo expansions impair embryonic stem cells multipotentiality, and thereby limit their clinical application. In the past few years, research collected attempts to explore new insights into the molecular mechanisms participate in the stemness capacity of embryonic stem cells. Along with these comments, modalities and strategies with the potential to maintain embryonic stem cells multipotentiality are of great interest. In this review, the authors attempted to discuss the pathways participating in the preservation of embryonic stem cells multipotentiality and emphasized the novel strategies that help to harness regenerative potential.

中文翻译：

胚胎干细胞多能性的分子机制一瞥：现状和未来展望。

胚胎干细胞具有向多种细胞谱系分化的潜能，并被证明是一种有效的治疗方法。但是，长时间的体外和离体扩增会损害胚胎干细胞的多能性，从而限制其临床应用。在过去的几年中，研究收集了尝试探索参与胚胎干细胞干能力的分子机制的新见解。与这些评论一起，具有维持胚胎干细胞多能性潜力的方法和策略引起了极大的兴趣。在这篇综述中，作者试图讨论参与保存胚胎干细胞多潜能的途径，并强调了有助于利用再生潜能的新颖策略。

更新日期：2020-02-04

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