2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, eight families), and animals (five species, five families). 2,4-DTBP is often a major component of violate or essential oils and it exhibits potent toxicity against almost all testing organisms, including the producers; however, it is not clear why organisms produce autotoxic 2,4-DTBP and its analogs. The accumulating evidence indicates that the endocidal regulation seems to be the primary function of the phenols in the producing organisms.

中文翻译：

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2,4-二叔丁基苯酚及其类似物的天然来源和生物活性。


2,4-二叔丁基苯酚或2,4-双(1,1-二甲基乙基)-苯酚(2,4-DTBP)是多种生物体产生的常见有毒次级代谢产物。 2,4-DTBP的生物来源和生物活性已得到充分研究，但苯酚尚未得到系统评价。本文对 2,4-DTBP 及其类似物进行了全面综述，重点介绍了天然来源和生物活性。 2,4-DTBP 已在至少 169 种细菌（10 科 16 种）、真菌（8 科 11 种）、硅藻（1 科 1 种）、地钱（1 科 1 种）、蕨类植物（2科2种）、裸子植物（1科4种）、双子叶植物（58科107种）、单子叶植物（8科22种）、动物（5科5种）。 2,4-DTBP 通常是违规精油或精油的主要成分，它对几乎所有测试生物体（包括生产者）都表现出强大的毒性；然而，目前尚不清楚为什么生物体会产生自毒性2,4-DTBP及其类似物。越来越多的证据表明，内杀调节似乎是生产生物体中酚类的主要功能。