用于区分结直肠癌亚型 MACROD2 状态的拷贝数变异模式,Frontiers in Bioengineering and Biotechnology

当前位置： X-MOL 学术 › Front. Bioeng. Biotech. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

用于区分结直肠癌亚型 MACROD2 状态的拷贝数变异模式
Frontiers in Bioengineering and Biotechnology ( IF 4.3 ) Pub Date : 2019-12-19 , DOI: 10.3389/fbioe.2019.00407
ShiQi Zhang _{1,

2} , XiaoYong Pan ₃ , Tao Zeng ₄ , Wei Guo ₅ , Zijun Gan ₆ , Yu-Hang Zhang ₆ , Lei Chen _{7,

8} , YunHua Zhang ₉ , Tao Huang ₆ , Yu-Dong Cai ₁

Affiliation

School of Life Sciences, Shanghai University, Shanghai, China.
Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Key Laboratory of System Control and Information Processing, Institute of Image Processing and Pattern Recognition, Ministry of Education of China, Shanghai Jiao Tong University, Shanghai, China.
Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Institute of Health Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Shanghai, China.
Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
College of Information Engineering, Shanghai Maritime University, Shanghai, China.
Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai, China.
Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei, China.

拷贝数变异 (CNV) 是 DNA 的一种常见结构变异模式，其突变率高于单核苷酸多态性 (SNP)，影响更大的基因组片段。CNV 与复杂疾病的发生有关，因此可用作识别新的癌症易感标志物或机制的策略。特别是，人类结直肠癌 (CRC) 中单 ADP-核糖基水解酶 2 (MACROD2) 基因座的频繁缺失会改变 DNA 修复和对 DNA 损伤的敏感性，并导致染色体不稳定。CNV与癌症之间的关系尚未得到解释。在本研究中，基于 SNP 阵列对 651 例 CRC 原发肿瘤的基因组变异分析，我们通过计算分析了 CNV 数据以选择与 MACROD2 的三种不同状态（杂合缺失、纯合缺失和正常状态）最相关的关键 SNP 位点，表明这些 CNV 可能在 CRC 肿瘤发生中发挥功能作用。本研究可为基于CNV的癌症发生机制提供新见解，为CRC的临床诊断和治疗预后提供参考。

"点击查看英文标题和摘要"

更新日期：2019-12-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文