Therapeutic strategies for thrombosis: new targets and approaches.,Nature Reviews Drug Discovery

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Therapeutic strategies for thrombosis: new targets and approaches.
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2020-03-04 , DOI: 10.1038/s41573-020-0061-0
Nigel Mackman ₁ , Wolfgang Bergmeier ₂ , George A Stouffer ₃ , Jeffrey I Weitz ₄

Affiliation

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge is the side effect of bleeding. Improved understanding of the mechanisms of haemostasis and thrombosis has revealed new targets for attenuating thrombosis with the potential for less bleeding, including glycoprotein VI on platelets and factor XIa of the coagulation system. The efficacy and safety of new agents are currently being evaluated in phase III trials. This Review provides an overview of haemostasis and thrombosis, details the current landscape of antithrombotic agents, addresses challenges with preventing thromboembolic events in patients at high risk and describes the emerging therapeutic strategies that may break the inexorable link between antithrombotic therapy and bleeding risk.

中文翻译：

血栓形成的治疗策略：新的目标和方法。

抗血小板药和抗凝剂是预防和治疗血栓形成的主要手段。然而，尽管抗血栓治疗取得了进展，但基本的挑战是出血的副作用。对止血和血栓形成机制的进一步了解揭示了减轻血栓形成的新靶标，具有减少出血的潜力，包括血小板上的糖蛋白VI和凝血系统的XIa因子。目前正在III期临床试验中评估新药的疗效和安全性。本评论概述了止血和血栓形成，详细介绍了抗血栓形成剂的现状，

更新日期：2020-03-04

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