Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)-Enol Esters,ACS Omega

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Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)-Enol Esters
ACS Omega ( IF 3.7 ) Pub Date : 2020-02-20 , DOI: 10.1021/acsomega.9b03936
Guangyuan Liu ₁ , Xingxing Zhang ₁ , Guanghua Kuang ₁ , Naihao Lu ₁ , Yang Fu ₁ , Yiyuan Peng ₁ , Qiang Xiao ₂ , Yirong Zhou _{1,

3}

Affiliation

A combination of ruthenium catalyst with silver salt and copper salt was proved to be a highly efficient protocol for the direct addition reaction of benzoic acids with unsymmetrical trifluoromethylated internal alkynes. Diverse trifluoromethyl group-substituted (E)-enol esters were readily obtained for a broad substrate scope in moderate to good yields with excellent regio- and stereoselectivities under mild reaction conditions.

中文翻译：

无磷Ru催化苯甲酸向三氟甲基化炔烃的区域和立体选择性加成，从而易于获得三氟甲基取代的（E）-烯醇酯

事实证明，钌催化剂与银盐和铜盐的组合是苯甲酸与不对称三氟甲基化内部炔烃直接加成反应的高效方法。在温和的反应条件下，以适中至良好的收率，以适中至良好的收率，在不同的三氟甲基取代的（E）-烯醇酯上均可以轻松获得不同的三氟甲基基团酯。

更新日期：2020-03-03

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