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Generation of Aryl Radicals from Aryl Hydrazines via Catalytic Iodine in Air: Arylation of Substituted 1,4-Naphthoquinones
ACS Omega ( IF 3.7 ) Pub Date : 2020-02-21 , DOI: 10.1021/acsomega.9b04014 Saibal Sar 1 , Jyoti Chauhan 1 , Subhabrata Sen 1
ACS Omega ( IF 3.7 ) Pub Date : 2020-02-21 , DOI: 10.1021/acsomega.9b04014 Saibal Sar 1 , Jyoti Chauhan 1 , Subhabrata Sen 1
Affiliation
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Arylated building blocks or heterocycles are key to myriad applications, including pharmaceutical drug discovery, materials sciences, and many more. Herein, we have reported a mild and efficient strategy for generation of aryl radicals by reacting appropriate aryl hydrazines with catalytic iodine in open air. The aryl radicals were quenched by diversely substituted 1,4-napthoquinones present in the reaction mixture to afford diversely substituted 2,3-napthoquinones in moderate to excellent yield. Control experiments provided insights into the putative reaction mechanism.
中文翻译：
通过空气中的催化碘从芳肼生成芳基自由基：取代的1,4-萘醌的芳构化
芳基化的结构单元或杂环是无数应用的关键，包括药物发现，材料科学等。本文中，我们已经报道了通过使合适的芳基肼与催化性碘在露天条件下反应而产生芳基的温和有效策略。用存在于反应混合物中的各种取代的1，4-萘醌淬灭芳基，以中等至优异的产率得到各种取代的2，3-萘醌。对照实验提供了对假定的反应机理的见解。
更新日期：2020-03-03
中文翻译：
通过空气中的催化碘从芳肼生成芳基自由基：取代的1,4-萘醌的芳构化
芳基化的结构单元或杂环是无数应用的关键，包括药物发现，材料科学等。本文中，我们已经报道了通过使合适的芳基肼与催化性碘在露天条件下反应而产生芳基的温和有效策略。用存在于反应混合物中的各种取代的1，4-萘醌淬灭芳基，以中等至优异的产率得到各种取代的2，3-萘醌。对照实验提供了对假定的反应机理的见解。
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