Hydrophilic astaxanthin: PEGylated astaxanthin fights diabetes by enhancing the solubility and oral absorbability.,Journal of Agricultural and Food Chemistry

当前位置： X-MOL 学术 › J. Agric. Food Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hydrophilic astaxanthin: PEGylated astaxanthin fights diabetes by enhancing the solubility and oral absorbability.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-03-02 , DOI: 10.1021/acs.jafc.0c00784
Yanjun Liu ₁ , Lu Yang ₁ , Yongli Guo ₁ , Ting Zhang ₁ , Xing Qiao ₁ , Jingfeng Wang ₁ , Jie Xu ₁ , Changhu Xue _{1,

2}

Affiliation

To develop hydrophilic astaxanthin with significantly enhanced solubility and stability, astaxanthin polyethylene glycol succinate (APGS) was synthesized by esterification of an astaxanthin succinate diester with polyethylene glycol 1000. The chemical structure of the hydrophilic derivative was confirmed by 1H-NMR and mass spectra. APGS showed better solubility than free astaxanthin in water and enhanced bioavailability as compared to that of free astaxanthin. Additionally, testing the effects on diabetes and inflammation in a high fat, high sucrose diet-induced insulin resistance mouse model demonstrated its benefits, suggesting that APGS maintains the health-promoting properties of astaxanthin. These results suggest that APGS could be a better source of hydrophilic astaxanthin.

中文翻译：

亲水性虾青素：聚乙二醇化虾青素通过增强溶解性和口服吸收性来对抗糖尿病。

为了开发具有显着增强的溶解性和稳定性的亲水性虾青素，虾青素琥珀酸酯二酸酯与聚乙二醇1000酯化合成了虾青素聚乙二醇琥珀酸酯（APGS）。亲水性衍生物的化学结构通过1 H-NMR和质谱证实。与游离虾青素相比，APGS在水中显示出比游离虾青素更好的溶解度，并提高了生物利用度。此外，在高脂肪，高蔗糖饮食诱导的胰岛素抵抗小鼠模型中测试对糖尿病和炎症的影响证明了其益处，表明APGS保持虾青素的健康促进特性。这些结果表明，APGS可能是亲水虾青素的更好来源。

更新日期：2020-03-06

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南