Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing,Advanced Functional Materials

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Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-28 , DOI: 10.1002/adfm.201910748
Xin Zhao ₁ , Yongping Liang ₁ , Ying Huang ₁ , Jiahui He ₁ , Yong Han ₁ , Baolin Guo _{1,

2}

Affiliation

Developing physical double‐network (DN) removable hydrogel adhesives with both high healing efficiency and photothermal antibacterial activities to cope with multidrug‐resistant bacterial infection, wound closure, and wound healing remains an ongoing challenge. An injectable physical DN self‐healing hydrogel adhesive under physiological conditions is designed to treat multidrug‐resistant bacteria infection and full‐thickness skin incision/defect repair. The hydrogel adhesive consists of catechol–Fe³⁺ coordination cross‐linked poly(glycerol sebacate)‐co‐poly(ethylene glycol)‐g‐catechol and quadruple hydrogen bonding cross‐linked ureido‐pyrimidinone modified gelatin. It possesses excellent anti‐oxidation, NIR/pH responsiveness, and shape adaptation. Additionally, the hydrogel presents rapid self‐healing, good tissue adhesion, degradability, photothermal antibacterial activity, and NIR irradiation and/or acidic solution washing‐assisted removability. In vivo experiments prove that the hydrogels have good hemostasis of skin trauma and high killing ratio for methicillin‐resistant staphylococcus aureus (MRSA) and achieve better wound closure and healing of skin incision than medical glue and surgical suture. In particular, they can significantly promote full‐thickness skin defect wound healing by regulating inflammation, accelerating collagen deposition, promoting granulation tissue formation, and vascularization. These on‐demand dissolvable and antioxidant physical double‐network hydrogel adhesives are excellent multifunctional dressings for treating in vivo MRSA infection, wound closure, and wound healing.

中文翻译：

物理双网络水凝胶粘合剂，具有快速的形状适应性，快速的自愈性，抗氧化剂和近红外/ pH刺激响应能力，可用于多种药物耐药细菌感染和可移动伤口敷料

开发具有高愈合效率和光热抗菌活性的物理双网（DN）可移动水凝胶粘合剂以应对多药耐药细菌感染，伤口闭合和伤口愈合仍然是一个挑战。在生理条件下，可注射的物理DN自修复水凝胶粘合剂可用于治疗多药耐药细菌感染和全层皮肤切口/缺损修复。的水凝胶粘合剂由儿茶酚的Fe ³⁺协调交联聚（癸二酸甘油酯） -共-聚（乙二醇） -克儿茶酚和四氢键交联的脲基嘧啶酮改性明胶。它具有出色的抗氧化性，NIR / pH响应性和形状适应性。此外，水凝胶具有快速的自我修复，良好的组织粘附性，降解性，光热抗菌活性以及近红外辐射和/或酸性溶液洗涤辅助去除性。体内实验证明，水凝胶对皮肤的创伤具有良好的止血作用，对耐甲氧西林的金黄色葡萄球菌（MRSA）具有很高的杀灭率，并且与医用胶和外科缝合线相比，能够更好地闭合和愈合皮肤切口。尤其是，它们可通过调节炎症，加速胶原蛋白沉积，促进肉芽组织形成和血管形成来显着促进全层皮肤缺损伤口愈合。

更新日期：2020-04-21

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