Abstract

Sulfones are versatile intermediates in organic synthesis and important building blocks in the construction of biological active molecules or functional materials. This review provides a summary of recent developments in the synthesis of sulfones.

1 Introduction

2 Classical Methods and Variants

2.1 Oxidation of Sulfides

2.2 Aromatic Sulfonylation

2.3 Alkylation/Arylation of Sulfinates

2.4 Addition to Alkenes and Alkynes

2.5 Miscellaneous Methods

3 Metal-Catalyzed Coupling Reactions

4 Sulfone Synthesis by C–H Functionalization

5 Sulfur Dioxide Based Three-Component Approaches

6 Biological Synthesis of Sulfones

7 Conclusion

Sulfones are versatile intermediates in organic synthesis and important building blocks in the construction of biological active molecules or functional materials. This review provides a summary of recent developments in the synthesis of sulfones.

1 Introduction

2 Classical Methods and Variants

2.1 Oxidation of Sulfides

2.2 Aromatic Sulfonylation

2.3 Alkylation/Arylation of Sulfinates

2.4 Addition to Alkenes and Alkynes

2.5 Miscellaneous Methods

3 Metal-Catalyzed Coupling Reactions

4 Sulfone Synthesis by C–H Functionalization

5 Sulfur Dioxide Based Three-Component Approaches

6 Biological Synthesis of Sulfones

7 Conclusion

中文翻译：

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砜合成的最新进展

摘要

砜是有机合成中的多功能中间体，是生物活性分子或功能材料构建中的重要组成部分。这篇综述总结了砜合成的最新进展。

1引言

2经典方法和变体

2.1硫化物的氧化

2.2芳族磺酰化

2.3磺酸盐的烷基化/丙烯酸化

2.4除烯烃和炔烃外

2.5其他方法

3金属催化的偶联反应

4 C–H官能团合成砜

5种基于二氧化硫的三组分方法

6砜的生物合成

7结论

砜是有机合成中的多功能中间体，是生物活性分子或功能材料构建中的重要组成部分。这篇综述总结了砜合成的最新进展。

1引言

2经典方法和变体

2.1硫化物的氧化

2.2芳族磺酰化

2.3磺酸盐的烷基化/丙烯酸化

2.4除烯烃和炔烃外

2.5其他方法

3金属催化的偶联反应

4 C–H官能团合成砜

5种基于二氧化硫的三组分方法

6砜的生物合成

7结论