Abstract

Two isomeric conformationally restricted analogues of 4-trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N-benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyldiazomethane and N-benzylmaleimide.

Two isomeric conformationally restricted analogues of 4-trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N-benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyldiazomethane and N-benzylmaleimide.

中文翻译：

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异构的6-三氟甲基-3-氮杂双环[3.1.0]己烷的合成：4-三氟甲基哌啶的构象受限类似物

摘要

设计了4-三氟甲基哌啶的两个异构体构象受限的类似物。由市售的N-苄基马来酰亚胺分四个步骤进行合成。关键反应是三氟甲基重氮甲烷与N-苄基马来酰亚胺之间的[3 + 2]环加成反应。

设计了4-三氟甲基哌啶的两个异构体构象受限的类似物。由市售的N-苄基马来酰亚胺分四个步骤进行合成。关键反应是三氟甲基重氮甲烷与N-苄基马来酰亚胺之间的[3 + 2]环加成反应。