The first total synthesis of 5-hydroxy-3-methyl-4-propylsulfanyl-5H-furan-2-one, a newly discovered natural product with anticancer property is described by two different routes. A sequence involving an incorporation of a methyl group via a Gilman reagent and a chemoselective reduction of a cyclic anhydride functionality are the key steps. The methods proposed start from easily available starting materials and allow ready preparation of the final compound in good overall yield.

Allium cepa - synthesis - Gilman reagent - chemopreventive - selective

中文翻译：

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首次全合成5-羟基-3-甲基-4-丙基硫烷基-5H-呋喃-2-酮：癌症的化学预防剂。

通过两种不同的途径描述了5-羟基-3-甲基-4-丙基硫烷基-5 H-呋喃-2-酮的首次全合成，这是一种新发现的具有抗癌性质的天然产物。关键步骤包括通过吉尔曼试剂引入甲基和环酸酐官能团化学选择性还原的序列。所提出的方法从容易获得的起始原料开始，并允许以良好的总收率容易地制备最终化合物。

洋葱头-合成-吉尔曼试剂-化学预防-选择性