The efficient synthesis of the tripeptidic building block Fmoc-Pro-Hyp(TBDPS)-Gly-OH and its application for the preparation of collagen model peptides (CMPs) has been achieved. The silyl ether protecting group prevents undesired side reactions during the CMP synthesis thereby facilitating purification and allowing for selective deprotection of the hydroxyproline residue without affecting the solid-supported CMP.

collagen - peptides - protecting groups - solid-phase synthesis - TBDPS silyl ether

中文翻译：

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Fmoc-Pro-Hyp（TBDPS）-Gly-OH的合成及其在制备胶原蛋白模型肽中的多功能基础

三肽结构单元Fmoc-Pro-Hyp（TBDPS）-Gly-OH的有效合成及其在制备胶原模型肽（CMPs）中的应用已经实现。甲硅烷基醚保护基防止CMP合成过程中不希望的副反应，从而促进纯化并允许对羟基脯氨酸残基进行选择性脱保护而不影响固体负载的CMP。

胶原蛋白-肽-保护基-固相合成-TBDPS甲硅烷基醚