Gram-scale synthesis of pure, bench-stable solid di-p-chlorobenzyl azodicarboxylate (DCAD) is performed in two steps without resorting to chromatography. This novel reagent effects Mitsunobu couplings with yields comparable to DEAD or DIAD, while addressing several of the drawbacks frequently associated with these common reagents.

Mitsunobu reaction - azo compounds - alcohols - esters - DCAD

中文翻译：

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用于Mitsunobu联轴器的二对氯苄基偶氮二羧酸酯（DCAD）的便捷制备

在不借助色谱法的情况下，分两步进行纯净，稳定的固体二-对氯苄基偶氮二羧酸酯（DCAD）的克规模合成。这种新颖的试剂以与DEAD或DIAD相当的产率实现了Mitsunobu偶联，同时解决了与这些普通试剂经常相关的一些缺点。

Mitsunobu反应-偶氮化合物-醇-酯-DCAD